| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22791 | Kinase inhibitor C1 | A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM. |
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| DC21417 | NSC 141562 | A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis. |
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| DC5132 | Tropisetron HCL | A potent SR-3 antagonist |
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| DC22530 | WEHI-345 analog | A potent Src inhibitor extracted from patent WO/2012003544A1.. |
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| DC20416 | Imipramine Blue | A potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
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| DC22933 | TLR7-Agonist-31 | A potent TLR7 agonist with EC50 of 59 nM.. |
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| DC22932 | TLR7-Agonist-54 | A potent TLR7 agonist with EC50 of 8.6 nM. . |
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| DC22934 | 3M-011 Featured | 3M-011 is a potent TLR7/8 agonist and cytokine inducer; stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells; induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice. |
|
| DC22922 | 3M-003 | A potent TLR7/8 agonist that induces robust production of the Th1-polarizing cytokines TNF-alpha and IL-12 from neonatal antigen-presenting cells (APCs).. |
|
| DC22393 | IW-927 | A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM). |
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| DC22618 | MMAD hydrochloride | A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).. |
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| DC22607 | Masitinib mesylate | A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays. |
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| DC23995 | Lck inhibitor 2 Featured | A potent tyrosine kinases inhibitor with IC50 of 13/9/3/26/2 nM for Lck/Btk/Lyn/Syk/Txk.. |
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| DC22374 | BMS-299897 | A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
|
| DC24011 | (±)-BI-D | A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase. |
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| DC20541 | RUNX1-IN-17 | A potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays. |
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| DC23288 | SMBA1 | A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
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| DC23992 | FAAH inhibitor 1 | A potent, and selective FAAH inhibitor with IC50 of 18 nM. |
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| DC22748 | UBP 302 | A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM. |
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| DC20475 | Nek2 inhibitor 72 | A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM. |
|
| DC23063 | FAUC 1104 | A potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment.. |
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| DC23064 | FAUC 1036 | A potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.. |
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| DC22801 | MK2 inhibitor III | A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM. |
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| DC20868 | CCG-203586 | A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM. |
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| DC22472 | Naltrexone Featured | A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
|
| DC22615 | Rosuvastatin | A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM. |
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| DC20318 | BCML | A potent, competitive inhibitor of quinine-activated bitter taste receptor T2R4 with IC50 of 59 nM.. |
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| DC20702 | Ilepatril | A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively. |
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| DC23394 | Dual BET-Kinase inhibitor 3 | A potent, dual BET bromodomain-kinase inhibitor with IC50 of 34, 1.1 and 1.1 nM for BRD4 BD1, JAK2 and FLT-3, respectively. |
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| DC20885 | CGP-74514A | A potent, dual CDC-like kinase (CLK)/CDK inhibitor with IC50 of 148, 111, 104, 382 and 573 nM for CLK1, CLK2, CLK4, CDK1 and CDK4, respectively.. |
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