| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC24059 | PI-103 hydrochloride Featured | A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively. |
|
| DC21562 | Pz-1 | A potent, dual pan-RET/VEGFR2 kinase inhibitor with IC50s of <1 nM for all RET, RET V804M and VEGFR2. |
|
| DC20542 | SA 16 | A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively. |
|
| DC22545 | TG 100572 hydrochloride | A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC23967 | TG 100572 | A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC20663 | AMG 511 | A potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
|
| DC11533 | PH-46A N-Methyl-D-Glucamine salt | A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
| DC11532 | PH-46A | A potent, first-in-class, oral small-molecule agent for the treatment of inflammatory bowel diseases.. |
|
| DC23211 | SKF 82958 Featured | A potent, full dopamine D1 agonist. |
|
| DC20939 | NCGC00379308 Featured | A potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation). |
|
| DC23958 | MRK-016 | A potent, functionally selective, CNS-penetrating and orally bioavailable inverse agonist of benzodiazepine site of GABAA α5 receptor with Ki of 0.8-1.5 nM for α1-, α2-, α3-, andα5-containing GABAA receptors. |
|
| DC20599 | 25CN-NBOH | A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
|
| DC20773 | BI-853520 | A potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays. |
|
| DC25066 | NVP-BDZ 824 | A potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM.. |
|
| DC21484 | PF-04802367 Featured | PF04802367 is a potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays; shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau; modulates tau phosphorylation in vitro and in vivo. |
|
| DC20794 | BIO-5192 | A potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM. |
|
| DC22760 | JJKK-048 | A potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL. |
|
| DC20501 | PI3Kβ and δ inhibitor 20a | A potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM). |
|
| DC24046 | VTP-27999 hydrochloride | A potent, highly selective renin inhibitor with IC50 of 0.47 nM. |
|
| DC22610 | VTP-27999 2,2,2-trifluoroacetate | A potent, highly selective renin inhibitor with IC50 of 0.47 nM. |
|
| DC22866 | BIO-7662 | A potent, highly selective α4β1 integrin antagonist with Kd of <10 pM. |
|
| DC21257 | AKT-IN-23 Featured | A potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma. |
|
| DC24003 | TC-S 7001(Azaindole 1) Featured | A potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively. |
|
| DC26096 | SR-8993 | A potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM. |
|
| DC20316 | Bantag-1 trifluoroacetate Featured | A potent, highly selective, peptide bombesin receptor subtype-3 (BRS-3) antagonist with IC50 of 2-8 nM for human and rodent BRS-3, displays 1000-fold selectivity over hNMBR and hGRPR, increases food intake and produces an obesity phenotype in mice.. |
|
| DC21861 | Z-DON | A potent, irreversible and cell permeable inhibitor of tissue transglutaminase with IC50 of 20 nM.. |
|
| DC21216 | L 682777 | A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC23777 | R 283 | A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC21001 | Estrone sulfamate | A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells. |
|
| DC22880 | MIV-6R | A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM. |
|
