Cat. No. | Product name | CAS No. |
DC9708 |
Paxalisib (GDC-0084)
Featured
GDC-0084 (RG7666), is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. |
1382979-44-3 |
DC10035 |
GDC-0326
GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). |
1282514-88-8 |
DC9592 |
GDC-0941 (dimethanesulfonate)
GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). |
957054-33-0 |
DC1054 |
GDC0941(Pictilisib)
Featured
GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. |
957054-30-7 |
DC5081 |
Apitolisib
Featured
GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases. |
1032754-93-0 |
DC8410 |
GNE-317
Featured
GNE-317 is a potent, brain-penetrant PI3K inhibitor. |
1394076-92-6 |
DC8257 |
GNE 477
Featured
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
1032754-81-6 |
DC8502 |
GNE-490
Featured
GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR. |
1033739-92-2 |
DC7953 |
GNE-493
Featured
GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
1033735-94-2 |
DC9515 |
PI3K inhibitor GS1059615
GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. |
958852-01-2 |
DC7141 |
Omipalisib
Featured
GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
1086062-66-9 |
DC9943 |
PI3Kδ inhibitor GS2269557
GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms. |
1254036-71-9 |
DC9944 |
PI3Kδ inhibitor GS2292767
GSK2292767 is a potent and selective PI3Kδ inhibitor. |
1254036-66-2 |
DC7156 |
IC-87114
Featured
IC-87114 was the first isoform-selective PI3K inhibitor. p110δ(IC50 = 0.13 μM) vs. p110α(IC50 = 200 μM), p110β(IC50 = 16 μM) and p110γ(IC50 = 61 μM). |
371242-69-2 |
DC7873 |
INK-055 (PI3Kγ inhibitor 1)
INK055 is a dual PI3Kg/d inhibitor. |
1172118-03-4 |
DC5072 |
Duvelisib (IPI-145, INK1197)
Featured
IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
1201438-56-3 |
DC9829 |
IPI-549
Featured
IPI-549 is an orally administered immuno-oncology development candidate that selectively inhibits PI3K-gamma. |
1693758-51-8 |
DC12386 |
Leniolisib (CDZ173)
Featured
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor currently in phase II/III clinical trials for the treatment of immunodeficiency disorders. |
1354690-24-6 |
DC10754 |
LX2343
Featured
LX-2343 is a novel non-ATP competitive PI3K inhibitor, negatively regulating AKT/mTOR signaling, thus promoting autophagy, and increasing A-beta clearance. |
333745-53-2 |
DC1058 |
LY294002
Featured
LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, respectively. |
154447-36-6 |
DC10219 |
LY3023414
Featured
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK. |
1386874-06-1 |
DC10871 |
MTX211
Featured
MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. |
1952236-05-3 |