NVP-BAG956(BAG 956)|cas 853910-02-8|DC Chemicals|Price|Buy

Cas No.:	853910-02-8
Chemical Name:	2-methyl-2-[4-(2-methyl-8-pyridin-3-ylethynyl-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile
Synonyms:	BAG956
SMILES:	CC1=NC2=C(C3=CC(C#CC4=CC=CN=C4)=CC=C3N=C2)N1C5=CC=C(C=C5)C(C#N)(C)C
Formula:	C₂₈H₂₁N₅
M.Wt:	427.5
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo, with IC50 values to be 56, 444, 34, 117 and 240 nM For PI3K p110 alpha, beta, delta and gamma and PDK1 kinases, respectively.For the detailed information of NVP-BAG956(BAG 956), the solubility of NVP-BAG956(BAG 956) in water, the solubility of NVP-BAG956(BAG 956) in DMSO, the solubility of NVP-BAG956(BAG 956) in PBS buffer, the animal experiment (test) of NVP-BAG956(BAG 956), the cell expriment (test) of NVP-BAG956(BAG 956), the in vivo, in vitro and clinical trial test of NVP-BAG956(BAG 956), the EC50, IC50,and Affinity of NVP-BAG956(BAG 956), Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47385	PI3K-IN-23	PI3K-IN-23 is an (E)-9-oxooctadec-10-en-12-ynoic acid analogue to promote glucose uptake with an EC50 value of 7.00 μM.
DC47384	PI3Kγ inhibitor 5	PI3Kγ inhibitor 5 is an inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with an IC50 value of 34 nM.
DC47382	MCX 28	MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.
DC47088	Amdizalisib	Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.
DC46520	iMDK quarterhydrate	iMDK quarterhydrate, a MDK-positive H441 and H520 lung adenocarcinoma cells inhibitor, suppresses the growth of H441 cells by inhibiting the PI3 kinase (PI3K) pathway and inducing apoptosis. iMDK quarterhydrate decreases MDK-induced migration, angiogenesis of endothelial cells and abrogats the progression and metastasis of NSCLC cells.
DC46457	PI3Kγ inhibitor 4	PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation.
DC46384	PI3K-IN-19 hydrochloride	PI3K-IN-19 hydrochloride is a phosphotidylinositol-3-kinase (PI3K) inhibitor extracted from patent WO2017153220, step 5.
DC46273	740 Y-P TFA	740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.
DC46266	PI3K-IN-20	PI3K-IN-20 is a PI3k inhibitor extracted from WO2017101847 A1, compound 1.
DC45823	AZ2	AZ2 is a highly selective PI3Kγ inhibitor. AZ2 can be used for the research of inflammatory and immune diseases.