Cat. No. | Product name | CAS No. |
DC8652 |
TGR-1202 hydrochloride(Umbralisib)
TGR-1202 hydrochloride is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-78-0 |
DC8653 |
TGR-1202(Umbralisib)
Featured
TGR-1202 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-67-7 |
DC7321 |
TGX221
Featured
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β . |
663619-89-4 |
DC5181 |
Voxtalisib Analogue
Featured
Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. |
1349796-36-6 |
DC8884 |
Voxtalisib (XL765, SAR245409)
Featured
Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. |
934493-76-2 |
DC10019 |
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
Featured
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. |
1383716-46-8 |
DC8650 |
Vps34-IN-1
Featured
VPS34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. |
1383716-33-3 |
DC1068 |
XL147 analogue(PI3K inhibitor X)
Featured
XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively. |
956958-53-5 |
DC1077 |
ZSTK474
Featured
ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM. |
475110-96-4 |
DC11906 |
Parsaclisib
Featured
Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies. |
1426698-88-5 |
DC7228 |
PF-04691502
Featured
PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. |
1013101-36-4 |
DC28718 |
PI3K-IN-9
PI3K-IN-9 (compound 1-14) is a potent and selective PI3Kδ inhibitor with an IC50 of 8.9 nM. |
2360875-63-2 |
DC28978 |
Copanlisib dihydrochloride (BAY 80-6946)
Featured
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has |
1402152-13-9 |
DC28984 |
PDK1/Akt/Flt Inhibitor 1
PDK1/Akt/Flt Inhibitor 1 is a PI3-K/Akt pathway inhibitor. |
331253-86-2 |
DC40762 |
TG 100713
TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively. |
925705-73-3 |
DC40777 |
MSC2360844(IOA-244 /roginolisib)
Featured
MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases. |
1305267-37-1 |
DC40778 |
MSC2360844 hemifumarate
MSC2360844 hemifumarate is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 hemifumarate shows highly selective against a panel of 278 additional kinases. |
1621688-31-0 |
DC41103 |
Quercetin D5
Quercetin D5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. |
263711-78-0 |
DC41371 |
Hirsutenone
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity. |
41137-87-5 |
DC42414 |
Zandelisib
Featured
Zandelisib is a phosphatidylinositol 3-kinase (PI3K) extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic. |
1401436-95-0 |
DC42415 |
IHMT-PI3Kδ-372
Featured
IHMT-PI3Kδ-372 is a potent and selective PI3Kδ with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research. |
2429889-62-1 |
DC42416 |
PI3Kδ-IN-8
PI3Kδ-IN-8 is a potent, selective and orally active PI3Kδ, with an IC50 of 3.3 nM. PI3Kδ-IN-8 shows selectivity for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50=377.2, 241.6, 17.9 nM, respectively). PI3Kδ-IN-8 has anti-tumor activity. |
2101518-75-4 |