Cat. No. | Product name | CAS No. |
DC23360 |
E67-2
E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM. |
1364914-62-4 |
DC10563 |
E-7046
Featured
E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities. |
1369489-71-3 |
DC5065 |
Golvatinib (E7050)
Featured
E-7050 is hepatocyte growth factor receptors (HGFR). |
928037-13-2 |
DC8488 |
LENVATINIB MESYLATE
Featured
E7080 (Lenvatinib) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. |
857890-39-2 |
DC7116 |
E7080 (Lenvatinib)
Featured
E7080 (Lenvatinib; Vargatef) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. |
417716-92-8 |
DC21898 |
E7090 succinate
E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
1879965-80-6 |
DC22085 |
E7090
E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM). |
1622204-21-0 |
DC11062 |
E7107
E7107 (E-7107) is a derivative of pladienolide that targets the SF3b subunit of the spliceosome, shows significant antitumor activity in vitro and in vivo. |
630100-90-2 |
DC10976 |
E-7386
Featured
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. |
1799824-08-0 |
DC9983 |
E-7449
Featured
E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2; enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. |
1140964-99-3 |
DC10784 |
E7820
Featured
E7820 is an angiogenesis inhibitor by suppressing integrin a2, a cell adhesion molecule expressed on endothelial cells. |
289483-69-8 |
DC9665 |
EAI045
Featured
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor. |
1942114-09-1 |
DCAPI1441 |
Seocalcitol
EB1089 is an analog of 1,25 dihydroxyvitamin D which acts as a vitamin D receptor (VDR). EB1089 is noted to reverse hypercalcemia and is a potent inhibitor of PTH-rP (parathyroid hormone-related peptide, PTHRP) in vitro. In studies utilizing a squamous ca |
134404-52-7 |
DC11037 |
EB-3D
EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines. |
1839150-63-8 |
DC9534 |
EBE-A22
Featured
EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. |
229476-53-3 |
DC20989 |
EBI-1051
EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM. |
1801896-05-8 |
DC11477 |
EBI-2511
Featured
EBI-2511 is a highly potent and orally active EZH2 inhibitor for the treatment of Non-Hodgkin’s Lymphoma. |
2098546-05-3 |
DC23818 |
EBI-907
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM. |
1581764-31-9 |
DC9848 |
Ebselen
Featured
Ebselen is a selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. |
60940-34-3 |
DC20123 |
EC0489
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-drug conjugate (SMDC). |
1096702-14-5 |
DC10277 |
EC330
Featured
EC330 is a leukemia inhibitory factor (LIF) inhibitor. |
2016795-77-8 |
DC10980 |
EC-359
EC-359 (EC359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay. |
2012591-09-0 |
DC20990 |
EC-70124
EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM). |
1185908-92-2 |
DC26057 |
Ecabet (sodium salt)
Featured
Ecabet is an antiulcerative and gastroprotective agent. |
86408-72-2 |
DCAPI1162 |
Ecdysone
Ecdysone |
3604-87-3 |
DCAPI1408 |
Echinocandin B0
Echinocandin B0 |
150283-04-8 |
DC9912 |
Echinocystic acid
Featured
Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. |
510-30-5 |
DCAPI1126 |
Econazole nitrate (Spectazole)
Econazole nitrate (Spectazole) |
24169-02-6 |
DC21514 |
Ecopladib
Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively. |
381683-92-7 |
DC10400 |
Ecteinascidin 770
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. |
114899-80-8 |
DCAPI1380 |
Edaravone (MCI-186)
Edaravone (MCI-186) |
89-25-8 |
DC10939 |
Edasalonexent
Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA). |
1204317-86-1 |
DC21002 |
Edelfosine
Featured
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells. |
77286-66-9 |
DC11398 |
Edicotinib(JNJ-40346527)
Featured
Edicotinib(JNJ-40346527)is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. |
1142363-52-7 |
DC23562 |
Edivoxetine
Edivoxetine (LY2216684) is a novel potent, selective norepinephrine reuptake inhibitor (NERI) being evaluated as adjunctive treatment for major depressive disorder (MDD).. |
1194508-25-2 |
DC23628 |
Edivoxetine hydrochloride
Edivoxetine (LY2216684) is a novel potent, selective norepinephrine reuptake inhibitor (NERI) being evaluated as adjunctive treatment for major depressive disorder (MDD).. |
1194374-05-4 |
DC10762 |
Edonerpic maleate
Featured
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ). |
519187-97-4 |
DC8305 |
Edoxaban
Featured
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention |
480449-71-6 |
DC8793 |
Edoxaban tosylate monohydrate
Featured
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention |
1229194-11-9 |
DC7819 |
Efaproxiral sodium
Featured
Efaproxiral Sodium is a synthetic allosteric modifier of hemoglobin, used for brain metastases originating from breast cancer. |
170787-99-2 |
DCAPI1479 |
Efavirenz
Efavirenz is a nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor which selectively inhibits the glucuronidation of 3'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt. Studies suggest that Efavirenz binds to a distinct site of reverse transcrip |
154598-52-4 |
DC9772 |
Efinaconazole(KP-103)
Featured
Efinaconazole(KP-103) is a novel triazole antifungal drug currently under development as a topical treatment for onychomycosis. |
164650-44-6 |
DC21515 |
Efipladib
Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition. |
381683-94-9 |
DC10261 |
Eflornithine hydrochloride hydrate
Eflornithine(Difluoromethylornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours. |
96020-91-6 |
DC9378 |
Efonidipine (hydrochloride monoethanolate)
Featured
Efonidipine(NZ-105) Hcl monoethanolate is a dual T-type and L-type calcium channel blocker (CCB). |
111011-76-8 |
DC20992 |
eFT226
eFT226 is a novel, potent and selective eIF4A inhibitor with anti-tumor activity in B-cell malignancies, promotes eIF4A binding to specific mRNA sequences and interferes with the assembly of the eIF4F initiation complex. |
|
DC9755 |
eFT508(Tomivosertib)
Featured
Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. |
1849590-01-7 |
DC22086 |
EG00229 free base
EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM. |
1018927-63-3 |
DC22087 |
EG01377
EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2. |
2227996-00-9 |
DC9270 |
Eg5 Inhibitor III(Dimethylenastron)
Featured
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound that acts as a strong, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5. |
863774-58-7 |
DC12303 |
Eg5 Inhibitor V, trans-24
Eg5 Inhibitor V, trans-24 is a potent and specific Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer. |
869304-55-2 |
DC23179 |
EGF816 mesylate
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively. |
1508250-72-3 |
DC11018 |
EGFR-IN-99
Featured
EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC). |
2068806-31-3 |
DC23677 |
Eggmanone
Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway. |
505068-32-6 |
DC7728 |
EHop-016
Featured
EHop-016 is a novel inhibitor of Rac GTPase with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3. |
1380432-32-5 |
DC7627 |
EHT-1864
Featured
EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. |
754240-09-0 |
DC11287 |
EHT 5372
Featured
EHT 5372 is a novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. |
1425945-63-6 |
DC7930 |
EI-1
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively. |
1418308-27-6 |
DC12233 |
Eicosadienoic acid
Featured
Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues. |
2091-39-6 |
DC20371 |
eIF4A3 inhibitor 53a
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM. |
2095486-67-0 |
DC20062 |
eIF4A3-IN-2
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. |
2095677-20-4 |
DC9684 |
EL102
Featured
EL-102 is a dual-inhibitor of apoptosis and angiogenesis, and exerts its action though the inhibition of Hif1 alpha induced hypoxic signalling pathways and induction of the Caspase 3/7 apoptotic cascade. |
1233948-61-2 |
DC10182 |
Elacestrant (dihydrochloride)
Featured
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
1349723-93-8 |
DC10208 |
Elacestrant S enantiomer
Elacestrant S enantiomer is an low activity enantiomer of elacestrant. Elacestrant (RAD1901) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
|
DC8301 |
Elacridar
Featured
Elacridar is an orally selectly potent P-glycoprotein (P-gp/ABCG1) inhibitor. |
143664-11-3 |
DC11192 |
Elacytarabine
Elacytarabine (CP-4055, CP4055) is a fatty acid derivative of cytarabine with potential antineoplastic activity. |
188181-42-2 |
DC10727 |
Elafibranor(GFT505)
Featured
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. |
923978-27-2 |
DC10032 |
Elagolix sodium
Featured
Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. |
832720-36-2 |
DC7407 |
Elagolix
Featured
Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. |
834153-87-6 |
DC22394 |
Elaiophylin
Elaiophylin (Gopalamicin. |
37318-06-2 |
DC22182 |
Elatol
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. |
55303-97-4 |
DC9295 |
Elbasvir(MK-8742)
Featured
Elbasvir (MK-8742) is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection. |
1370468-36-2 |
DCAPI1410 |
Eldecalcitol
Featured
Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is more efficaci |
104121-92-8 |
DC9980 |
Eleclazine(GS-6615)
Featured
Eleclazine(GS-6615) is a selective late sodium current inhibitor. |
1443211-72-0 |
DC11551 |
Elenbecestat
Featured
Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease.. |
1388149-39-0 |
DC3156 |
Elesclomol (STA-4783)
Featured
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
488832-69-5 |
DC21774 |
Eletriptan
Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist. |
143322-58-1 |
DC8323 |
Eletriptan HBr
Featured
Eletriptan HBr is an orally active, selective 5-HT1B/1D receptor agonist. |
177834-92-3 |
DC9291 |
Eliglustat hemitartrate (Genz-112638)
Featured
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase. |
928659-70-5 |
DC9290 |
Eliglustat(Genz-99067)
Featured
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase. |
491833-29-5 |
DC7772 |
Elinogrel
Elinogrel is a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. |
936500-94-6 |
DC8268 |
Eliprodil
Featured
Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. |
119431-25-3 |
DC10410 |
Ellipticine hydrochloride
Featured
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. |
5081-48-1 |
DC8325 |
Ellipticine
Featured
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
519-23-3 |
DC7786 |
ELN 441958
Featured
ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor.IC50 value: 0.26 nM (Ki)Target: B1 Receptorin vitro: ELN-441958 is a novel small molecule bradykinin B1 receptor antagonist, based on the inhibition of agonist-induced increases in intracellular calcium in native and recombinant cells. ELN-441958 does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM, showing that it is highly selective for B1 over B2 receptors. ELN-441958 also displays good selectivity for B1 over other receptors examined in a broad screening panel. It is >500-fold and >2000-fold selective for the B1 receptor over the human μ- and δ-opioid receptor, the most potent off-target activity identified. In IMR-90 cells expressing the native human B1 receptor, ELN-441958 produced a concentration-dependent antagonism of the DAKD-induced calcium mobilization with a KB of 0.12 nM. [1]in vivo: ELN-441958 is essentially completely absorbed and produces high plasma levels after oral administration in rhesus monkeys.ELN-441958 has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. ELN-441958 has high oral exposure and moderate plasma half-lives in rats and rhesus monkeys. The oral availability of ELN441958 in rats was 57%. ELN-441958 dose-dependently reduced carrageenan-induced thermal hyperalgesia in a rhesus monkey tail-withdrawal model, with an ED50 3 mg/kg s.c. [1] |
913064-47-8 |
DC10740 |
ELN484228
Featured
ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease. |
312-63-0 |
DC7779 |
ELND0006
ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. |
1333990-84-3 |
DCAPI1504 |
Elocalcitol
Elocalcitol |
199798-84-0 |
DC20268 |
ELQ300
Featured
ELQ300 is a novel inhibitor of the mitochondrial cytochrome bc1 complex (complex III in the electron transport chain). |
1354745-52-0 |
DCAPI1196 |
Eltrombopag (SB-497115-GR)
Featured
Eltrombopag (SB-497115-GR) |
496775-61-2 |
DC8369 |
Eltrombopag olamine
Featured
Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. |
496775-62-3 |
DC23523 |
Elubrixin tosylate
Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist. |
960495-43-6 |
DC21618 |
Elubrixin
Elubrixin (SB-656933, GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist. |
688763-64-6 |
DC8625 |
Eluxadoline Dihydrochloride
Featured
Eluxadoline Dihydrochloride is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. |
864825-13-8 |
DC8626 |
Eluxadoline
Featured
Eluxadoline is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. |
864821-90-9 |
DC4235 |
Elvitegravir(GS9137)
Featured
Elvitegravir (EVG) is a drug used for the treatment of HIV infection. It acts as an integrase inhibitor. |
697761-98-1 |
DC21465 |
EMA300
EMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor, produces analgesia in rodent model of neuropathic pain.. |
136676-76-1 |
DC10870 |
EMA400
Featured
EMA400 is a potent and highly selective AT2R antagonist. |
152362-51-1 |
DC10869 |
Olodanrigan(EMA401)
Featured
EMA401(Olodanrigan) is a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. |
1316755-16-4 |
DC8706 |
Emamectin Benzoate
Emamectin Benzoate works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods. |
155569-91-8 |
DC7731 |
Emapunil(AC-5216)
Featured
Emapunil(AC-5216;XBD-173) is a translocator protein |
226954-04-7 |
DC11028 |
EMD-281014 hydrochloride
EMD-281014 hydrochloride is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels. |
443144-27-2 |
DC11027 |
EMD-281014
EMD-281014 is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels. |
443144-26-1 |
DC7117 |
EMD534085
EMD534085 is a kinesin inhibitor currently in clinical development. |
858668-07-2 |
DC9620 |
EMD638683
Featured
EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM. |
1181770-72-8 |
DC8885 |
EMICORON
Featured
EMICORON is a novel G-quadruplex (G4) ligand showing high selectivity for G4 structures over the duplex DNA, causing telomere damage and inhibition of cell proliferation in transformed and tumor cells. |
1422423-23-1 |
DC9771 |
ACU4429,ACU 4429,ACU-4429
Featured
Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. |
1141934-97-5 |
DC10314 |
Emixustat
Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. |
1141777-14-1 |
DC22785 |
EML-405
EML-405 (EML405) is a small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 14 uM. |
2101954-79-2 |
DC10301 |
Emodepside
Featured
Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. |
155030-63-0 |
DC5018 |
Empagliflozin (BI-10773)
Featured
Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), which is found almost exclusively in |
864070-44-0 |
DC23171 |
Empesertib(BAY 1161909)
Featured
Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM. |
1443763-60-7 |
DC9762 |
Emricasan
Featured
Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor. |
254750-02-2 |
DC12273 |
EMT inhibitor-1
EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. |
1638526-21-2 |
DC5902 |
Emtricitabine
Featured
Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reve |
143491-57-0 |
DC23108 |
EN460
Featured
EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM). |
496807-64-8 |
DC24204 |
EN6
Featured
EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. |
1808714-73-9 |
DC20892 |
Enadoline
Enadoline (CI 977. |
124378-77-4 |
DCAPI1334 |
Enalapril maleate (Vasotec)
Enalapril maleate (Vasotec) |
76095-16-4 |
DC8177 |
Enclomiphene citrate
Featured
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. |
7599-79-3 |
DC9959 |
Endoxifen (E-isomer)
Featured
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). |
1197194-61-8 |
DC8403 |
Endoxifen (Z-isomer hydrochloride)
Featured
Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2. |
1032008-74-4 |
DC8265 |
Endoxifen
Featured
Endoxifen is a Estrogen receptor α (ERα) ligand; potent antiestrogen,an active metabolite of the cancer drug tamoxifen. |
112093-28-4 |
DC7589 |
Eniporide(EMD96785)
Featured
Eniporide is a The Na(+)/H(+) exchange inhibitor. |
176644-21-6 |
DC20993 |
ENMD-1068
Featured
ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling. |
789488-77-3 |
DC7118 |
ENMD-2076
Featured
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. |
934353-76-1 |
DC9247 |
AP-III-a4 hydrochloride
Featured
ENOblock Hcl(AP-III-a4 Hcl) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. |
2070014-95-6 |
DC7119 |
ENO block(AP-III-a4)
Featured
ENOblock(AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. |
1177827-73-4 |
DC8778 |
Enocitabine
Enocitabine is an anti-tumor agent and an antineoplastic. A derivative of Cytarabine. |
55726-47-1 |
DC20018 |
Enocyanin
Featured
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. |
11029-12-2 |
DC10547 |
Ensartinib
Featured
Ensartinib is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer. |
1365267-27-1 |
DC8321 |
Entacapone
Featured
Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. |
130929-57-6 |
DC4208 |
Entecavir Monohydrate
Featured
Entecavir hydrate belongs to the family of medicines called antivirals. |
209216-23-9 |
DC8881 |
Entecavir
Entecavir is a deoxyguanosine nucleoside analogue with antiviral activity against the hepatitis B virus (HBV). |
142217-69-4 |
DC6909 |
Entinostat (MS-275)
Featured
Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2. |
209783-80-2 |
DC24202 |
Ent-kaurene
Featured
Ent-kaurene is a tetracyclic diterpene consisting of ent-kaurane, where the 6-methyl group is replaced by methylene. It derives from a hydride of an ent-kaurane. |
562-28-7 |
DC8300 |
Entrectinib (RXDX-101)
Featured
Entrectinib (RXDX-101), a potent and selective small molecule inhibitor of TrkA/B/C, ROS1, and ALK kinases, has demonstrated early clinical activity when orally administered intermittently under fasting conditions. |
1108743-60-7 |
DC21856 |
Enviroxime
Enviroxime (Zinviroxime. |
72301-79-2 |
DC20848 |
Enzaplatovir
Enzaplatovir (BTA-585, BTA-C585) is an orally bioavailable RSV fusion protein inhibitor for the treatment of respiratory syncytial virus infections.. |
1323077-89-9 |
DC5057 |
Enzastaurin (LY317615)
Featured
Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3. |
170364-57-5 |
DC20950 |
EOAI3402143
EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor with increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130. |
1699750-95-2 |
DC8389 |
Epacadostat (INCB024360)
Featured
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2. |
1204669-58-8 |
DCAPI1356 |
Epalrestat
Featured
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy. |
82159-09-9 |
DC21601 |
Epertinib
Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively. |
908305-13-5 |
DC20374 |
EphB3-IN-1
EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM. |
1980036-18-7 |
DC8856 |
EPI-001
Featured
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator |
227947-06-0 |
DC11433 |
Vatiquinone
EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone. |
1213269-98-7 |
DC8693 |
Epiandrosterone
Featured
Epiandrosterone is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase from the adrenal hormone DHEA. |
481-29-8 |
DC9363 |
Epibrassinolide
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor c |
78821-43-9 |
DC23071 |
Epigoitrin
Featured
Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix, exhibit in vitro cooperation, they have in vitro anti-virus activity. |
1072-93-1 |
DC9467 |
Epinastine
Featured
Epinastine(WAL801) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
80012-43-7 |
DCAPI1014 |
Eplerenone
Featured
Eplerenone, also known as Inspra and CGP-30083, is a selective aldosterone receptor antagonist used to treat hypertension and congestive heart failure. Eplerenone provides marked protection against vascular injury in the kidney and heart. |
107724-20-9 |
DC23786 |
Epolactaene
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
167782-17-4 |
DC7120 |
Epothilone A
Epothilone A is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis. |
152044-53-6 |
DC4198 |
Epothilone B
Featured
Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
152044-54-7 |
DC7012 |
Epothilone D
Epothilone D(Desoxyepothilone B; KOS 862) is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. |
189453-10-9 |
DC8030 |
Epoxomicin
Featured
Epoxomicin is a selective and irreversible inhibitor of 20S proteasome with an IC50 value of 4 nM. |
134381-21-8 |
DC12311 |
Eprobemide (LIS 630)
Featured
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A. |
87940-60-1 |
DC9171 |
Eprosartan mesylate
Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively. |
144143-96-4 |
DC9260 |
Eptapirone
Featured
Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family. |
179756-58-2 |
DC5182 |
EPZ004777
Featured
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. |
1338466-77-5 |
DC7121 |
EPZ005687
Featured
EPZ-005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
1396772-26-1 |
DC7927 |
EPZ011989
Featured
EPZ011989 is a potent, orally-available EZH2 Inhibitor. |
1598383-40-4 |
DC8012 |
EPZ015666
Featured
EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. |
1616391-65-1 |
DC9267 |
EPZ015866
Featured
EPZ015866(GSK591) is a potent, selective PRMT5 inhibitor. |
1616391-87-7 |
DC26000 |
EPZ019997
Featured
EPZ019997 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). |
1628925-77-8 |
DC9822 |
EPZ020411 HCl
Featured
EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. |
1700663-41-7 |
DC12529 |
EPZ020411 dihydrochloride
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
2095432-47-4 |
DC23134 |
EPZ020411 hydrochloride
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
2070015-25-5 |
DC20996 |
EPZ 025654
EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM. |
1888328-89-9 |
DC22657 |
EPZ-030456
EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM. |
1808011-23-5 |
DC10887 |
EPZ031686
Featured
EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively. |
2095161-11-6 |
DC4242 |
Pinometostat(EPZ5676)
Featured
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. |
1380288-87-8 |
DC7122 |
Tazemetostat(EPZ-6438)
Featured
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity with Ki value of 2.5±0.5 nM. |
1403254-99-8 |
DC8595 |
Equisetin
Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity. |
57749-43-6 |
DC20997 |
ER000444793
Featured
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM. |
792957-74-5 |
DC22468 |
ER-27319 maleate
ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk. |
1204480-26-1 |
DC22090 |
ER-464195-01
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
859218-37-4 |
DC22433 |
ER-819762
ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay. |
1155773-15-1 |
DC7410 |
Erastin
Featured
Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. |
571203-78-6 |
DC11238 |
ERD03
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
|
DC11387 |
Erdafitinib
Featured
Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1-4 with IC50 values of 1.2, 2.5, 3.0 and 5.7nM, respectively. |
1346242-81-6 |
DCAPI1365 |
Erdosteine
Erdosteine |
84611-23-4 |
DC21416 |
ERGi-USU
ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. |
1147-56-4 |
DC23055 |
Erianin
Featured
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis. |
95041-90-0 |
DCAPI1539 |
Eribulin Mesylate
Featured
Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin is also known as E7389 and ER-086526, and also carries the US NCI designation NSC-707389. It is used to treat certain patients with breast cancer and liposarcoma. |
441045-17-6 |
DCAPI1516 |
Eribulin
Eribulin Mesylate (E7389 Mesylate), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. |
253128-41-5 |
DC22441 |
Eritoran tetrasodium
Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist.. |
185954-98-7 |
DC26018 |
ERK5-IN-2
Featured
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. |
1888305-96-1 |
DC22486 |
Erlotinib mesylate
Featured
Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. |
248594-19-6 |
DC2101 |
Erlotinib free base
Featured
Erlotinib (OSI-744; NSC 718781; R1415) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
183321-74-6 |
DC3139 |
Erlotinib hydrochloride
Featured
Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM. |
183319-69-9 |
DCAPI1477 |
Ertapenem
Featured
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz. |
153832-46-3 |
DCAPI1476 |
Ertapenem Sodium
Featured
Ertapenem Sodium |
153773-82-1 |
DC8440 |
Erythromycin Cyclocarbonate
Featured
Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. |
55224-05-0 |
DC7409 |
E-Mycin
Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
114-07-8 |
DC20244 |
ES9-17
Featured
ES9-17 is a novel CME inhibitor. |
55854-43-8 |
DC10211 |
Escin
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). |
6805-41-0 |
DC4171 |
Escitalopram oxalate
Featured
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
219861-08-2 |
DC21000 |
ESI-05
Featured
ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM. |
5184-64-5 |