m-PEG5-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

XY028-140 (MS-140) is a potent and selective PROTAC-based CDK4/CDK6 kinase degrader. XY028-140 specifically inhibits RB-E2F signaling and reduces CDK4 and CDK6 protein levels in a dose- and time-dependent manner in vitro. In addition, XY028-140 can degrade its targets by linking them with ubiquitin-proteasome mechanism. Further, the degradation of CDK4/6 protein by XY028-140 is specifically mediated by CRBN. Therefore, XY028-140 effectively and selectively inhibits and degrades CDK4/6 kinase by targeting CDK4/6 kinase in CDK4/6i-S (CDK4/6 inhibitor-sensitive) tumor cells to the CRL4-CRBN-E3 ubiquitin complex. Compared with CDK6 wild-type cells, XY028-140 treatment of cells expressing wild-type or mutation-activated CDK6 resulted in a more effective degradation of CDK6 (S178P).

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.