| DC45241 |
Mal-amido-PEG5-acid |
Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45242 |
Azido-PEG7-NHS ester |
Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45243 |
Propargyl-PEG11-amine |
Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45244 |
Propargyl-PEG11-acid |
Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45245 |
Mal-PEG10-acid |
Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45246 |
Propargyl-PEG12-acid |
Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45247 |
Propargyl-PEG13-OH |
Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45248 |
Mal-amido-PEG7-NHS ester |
Mal-amido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45249 |
Mal-PEG10-Boc |
Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45250 |
Mal-PEG10-NHS ester |
Mal-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45251 |
Propargyl-PEG13-Boc |
Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45252 |
m-PEG14-NHS ester |
m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45253 |
Fmoc-PEG9-NHS ester |
Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45254 |
Fmoc-PEG10-NHS ester |
Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45255 |
Bis-sulfone-PEG4-Tetrazine |
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45256 |
Azido-PEG10-propargyl |
Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45257 |
Benzyl-PEG10-Ots |
Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC45258 |
Benzyl-PEG12-Ots |
Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC55003 |
XY028-140 (MS140)
Featured
|
XY028-140 (MS-140) is a potent and selective PROTAC-based CDK4/CDK6 kinase degrader. XY028-140 specifically inhibits RB-E2F signaling and reduces CDK4 and CDK6 protein levels in a dose- and time-dependent manner in vitro. In addition, XY028-140 can degrade its targets by linking them with ubiquitin-proteasome mechanism. Further, the degradation of CDK4/6 protein by XY028-140 is specifically mediated by CRBN. Therefore, XY028-140 effectively and selectively inhibits and degrades CDK4/6 kinase by targeting CDK4/6 kinase in CDK4/6i-S (CDK4/6 inhibitor-sensitive) tumor cells to the CRL4-CRBN-E3 ubiquitin complex. Compared with CDK6 wild-type cells, XY028-140 treatment of cells expressing wild-type or mutation-activated CDK6 resulted in a more effective degradation of CDK6 (S178P). |
|
| DC45311 |
Thalidomide-O-C6-NH2 |
Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC45314 |
Thalidomide-O-amido-C8-NH2 hydrochloride |
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
|
| DC45696 |
Lenalidomide-6-F |
Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC. |
|
| DC45697 |
Lenalidomide-4-aminomethyl |
Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC. |
|
| DC45698 |
Lenalidomide-4-aminomethyl hydrochloride |
Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC |
|
| DC45699 |
Lenalidomide-5-Br |
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC. |
|
| DC45700 |
Lenalidomide-5-aminomethyl |
Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC. |
|
| DC45701 |
Pomalidomide-PEG3-C2-NH2 hydrochloride |
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC45702 |
Thalidomide-NH-C6-NH2 hydrochloride |
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC45703 |
(S,R,S)-AHPC-C3-NH2 hydrochloride |
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. |
|
| DC45704 |
Thalidomide-O-C4-NH2 |
Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
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