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PROTACs

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Cat. No. Product Name Field of Application Chemical Structure
DC45244 Propargyl-PEG11-acid Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45245 Mal-PEG10-acid Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45246 Propargyl-PEG12-acid Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45247 Propargyl-PEG13-OH Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45248 Mal-amido-PEG7-NHS ester Mal-amido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45249 Mal-PEG10-Boc Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45250 Mal-PEG10-NHS ester Mal-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45251 Propargyl-PEG13-Boc Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45252 m-PEG14-NHS ester m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45253 Fmoc-PEG9-NHS ester Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45254 Fmoc-PEG10-NHS ester Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45255 Bis-sulfone-PEG4-Tetrazine Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45256 Azido-PEG10-propargyl Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC45257 Benzyl-PEG10-Ots Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
DC45258 Benzyl-PEG12-Ots Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
DC55003 XY028-140 (MS140) Featured XY028-140 (MS-140) is a potent and selective PROTAC-based CDK4/CDK6 kinase degrader. XY028-140 specifically inhibits RB-E2F signaling and reduces CDK4 and CDK6 protein levels in a dose- and time-dependent manner in vitro. In addition, XY028-140 can degrade its targets by linking them with ubiquitin-proteasome mechanism. Further, the degradation of CDK4/6 protein by XY028-140 is specifically mediated by CRBN. Therefore, XY028-140 effectively and selectively inhibits and degrades CDK4/6 kinase by targeting CDK4/6 kinase in CDK4/6i-S (CDK4/6 inhibitor-sensitive) tumor cells to the CRL4-CRBN-E3 ubiquitin complex. Compared with CDK6 wild-type cells, XY028-140 treatment of cells expressing wild-type or mutation-activated CDK6 resulted in a more effective degradation of CDK6 (S178P).
DC45311 Thalidomide-O-C6-NH2 Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45314 Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
DC45696 Lenalidomide-6-F Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC.
DC45697 Lenalidomide-4-aminomethyl Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC.
DC45698 Lenalidomide-4-aminomethyl hydrochloride Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
DC45699 Lenalidomide-5-Br Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC.
DC45700 Lenalidomide-5-aminomethyl Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC.
DC45701 Pomalidomide-PEG3-C2-NH2 hydrochloride Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45702 Thalidomide-NH-C6-NH2 hydrochloride Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45703 (S,R,S)-AHPC-C3-NH2 hydrochloride (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
DC45704 Thalidomide-O-C4-NH2 Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45705 Thalidomide-NH-PEG1-NH2 hydrochloride Featured Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45706 Pomalidomide-C3-NH2 hydrochloride Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45707 Pomalidomide-C3-NH2 Pomalidomide-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

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