| DC86120 |
LIPID 10
Featured
|
Lipid 10 is a novel ionizable cationic lipid be used for delivery of therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted with Lipid 10-LNP. |
|
| DC65327 |
306-N16B (Disulpax)
Featured
|
306-N16B is a lipidnanoparticle, and allows systemic codelivery of Cas9 mRNA and sgRNA. 306-N16B can transport mRNA to the pulmonaryendothelial cell. 306-N16B can be used for research of genome editing-based therapies. Based on the same lipid libraries with 306-O12B, the researchers also found that N-series ionizable lipids were able to selectively deliver mRNA to the lungs of mice. Compared with the liver-targeted O-series ionizable lipids which contained ester bond in lipid tail found in previous work, such as 306-O12B, the N-series ionizable lipids with
the lipid tail containing amide bond prefer to deliver mRNA to the lung. As a N-series ionizable lipid, the chemical structure of the 306-N16B is shown in Figure 4a,b. The difference of organ targeting may be due to their adsorption
of different protein coronas during blood circulation caused
by their different structures mentioned earlier.It has
shown that the second major protein of the protein
corona adsorbed by liver-targeting 306-O12B iLNPs was apolipoprotein
E (ApoE), while the three dominant proteins in the
protein corona adsorbed by lung-targeting 306-N16B iLNPs
were serum albumin, fibrinogen beta chain, and fibrinogen
gamma chain. However, the 306-N16B iLNPs showed less
organ selectivity when systematically codelivered Cas9
mRNA and sgRNA in vivo, which could simultaneously
activate tdTomato expression in the liver and lung of Ai14
mice, whereas single mRNA delivery could almost
exclusively deliver mRNA to the lungs. This surprising phenomenon
requires further investigation. Both the change of
iLNPs charge and the change of lipids functional group
can influence the distribution of iLNPs in vivo due to
the altering of protein corona composition. Therefore,
it is possible to control the organ targeting of iLNPs by
controlling the composition of the outer protein corona of
iLNPs. |
|
| DC65328 |
AA-T3A-C12 |
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid) with high potency and selectivity to deliver RNA payloads to activated fibroblasts. HSP47 siRNA (siHSP47)-loaded AA-T3A-C12 LNP achieves ~65% knockdown and dramatically reduces liver fibrosis, which significantly outperforms the benchmark DLin-MC3-DMA (MC3) LNP. |
|
| DC65329 |
ALC-0315 analogue-2
Featured
|
ALC-0315 analogue-2 is an analogue of ALC-0315. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine. |
|
| DC65332 |
Lipid 6 |
Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles . |
|
| DC65333 |
A2-Iso5-4DC19
Featured
|
A2-Iso5-4DC19 is a lipidoid compound. A2-Iso5-4DC19 is an effective carrier for the delivery of an agent such as a polynucleotide to a cell. |
|
| DC65334 |
Lipid 15
Featured
|
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles . |
|
| DC65335 |
LNP Lipid-5
Featured
|
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles . |
|
| DC60465 |
Lipid R6 |
R6 is a new ionizable lipid driven from AI-Guided Ionizable Lipid Engineering (AGILE) platform for mRNA delivery. R6 LNPs exhibits a 5-fold increase in transfection potency in RAW 264.7 and shows its potential to be utilized for the development of non-viral mRNA delivery vectors for immune cells. |
|
| DC60466 |
H9 |
H9 is a new ionizable lipid driven from AI-Guided Ionizable Lipid Engineering (AGILE) platform for mRNA delivery. H9 LNPs shows superior mRNA transfection potency compared to LNPs containing (D-Lin-MC3-DMA). |
|
| DC60467 |
C12-TLRa |
C12-TLRa is an adjuvant lipidoid. C12-TLRa substitution can enhance the immunogenicity of clinically relevant SARS-CoV-2 mRNA-LNP vaccines, which holds translational potential. |
|
| DC65349 |
ALC-0315 analgous-3
Featured
|
ALC-0315 analgous-3 is an butanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315. |
|
| DC65350 |
BP Lipid 101 |
BP Lipid 101 is an amino ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
| DC65351 |
BP Lipid 102 |
BP Lipid 102 is an ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has ethanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. Both esters of the lipid are at the C6 position relative to the amine. The lipid can be used for mRNA delivery. Reagent grade, for research purpose. |
|
| DC65352 |
BP Lipid 103 |
BP Lipid 103 is an amine ionizable lipid analogous to SM-102. The ethanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research only. |
|
| DC65353 |
BP Lipid 104 |
BP Lipid 104 is an ionizable lipid with ethanolamine head to enhance mRNA encapsulation. Ester linkages at C7 position relative to amine are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
.gif)
|
| DC65354 |
BP Lipid 105 |
BP Lipid 105 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 relative to amine nitrogen, improve tissue clearance. Reagent grade, for research purpose. |
|
| DC65355 |
BP Lipid 106 |
BP Lipid 106 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose. |
|
| DC65356 |
BP Lipid 107 |
BP Lipid 107 is an ionizable amino lipid with both ester linkages located at C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. Reagent grade, for research purpose. |
|
| DC65357 |
BP Lipid 109 |
BP Lipid 109 is an amine lipid which has long (11 carbons) lipid tail on the primary ester. Both esters are located at C7 position and the head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. |
|
| DC65358 |
BP Lipid 110 |
BP Lipid 110 is an ionizable amino lipid with ester likages located at C6 and C7 position relative to amine. The ethanolamine moiety can enhance encapsulation of mRNA. The lipid has a relatively short primary ester lipid tail (7C). Reagent grade, for research purpose. |
|
| DC65359 |
BP Lipid 111 |
BP Lipid 111 is an ionizable amine lipid with ethanolamine head for efficient mRNA encapsulation. The lipid has two ester linkages at C6 and C7 position. The C6 ester has a 9-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
| DC65360 |
BP Lipid 112 |
BP Lipid 112 is an amine lipid with two ester linkages at C6 and C7 position. The C6 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
| DC65361 |
BP Lipid 113 |
BP Lipid 113 is an ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 and C8 position relative to the amine nitrogen. The primary ester at C6 position has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
| DC65362 |
BP Lipid 114 |
BP Lipid 114 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds are located at C6 and C8 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose. |
|
| DC65363 |
BP Lipid 116 |
BP Lipid 116 is an ionizable amine lipid with ethanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated, at C7 adn C6 position relative to amine, in the structure to increase tissue clearance of the lipid in the liver. The primary ester has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
| DC65364 |
BP Lipid 117 |
BP Lipid 117 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 and C6 relative to amine nitrogen, are introduced in the structure to improve tissue clearance. Reagent grade, for research purpose. |
|
| DC65365 |
BP Lipid 118 |
BP Lipid 118 is an amino ionizable lipid with ester bonds located at C7 and C6 poisiton relative to nitrogen. The ethanolamine head can effectively improve mRNA encapsulation while introduction of ester bonds improve tissue clearance. The primary ester contains a long 11 carbons tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose. |
|
| DC65366 |
BP Lipid 119 |
BP Lipid 119 is an ionizable amino lipid with both ester linkages located at C7 and C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The ethanolamine head help encapsulation of mRNA while the introduction of secondary ester can improve protein expression. Reagent grade, for research purpose. |
|
| DC65367 |
BP Lipid 120 |
BP Lipid 120 is an amine lipid with two ester linkages at C7 and C8 position relative to the amine. The C7 ester has a medium length (9 carbons) lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
|
