| DC65433 |
BP Lipid 230 |
BP Lipid 229 is an amino ionizable lipid with an ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid tails have 6 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
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| DC65434 |
SM102 Analog 1
Featured
|
An analog of SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C7 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. |
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| DC65435 |
BP Lipid 306 |
BP Lipid 306 is an amino ionizable lipid with an butanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid tails have 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. |
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| DC65437 |
LNP Lipid-2
Featured
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LNP Lipid-2 is a lipid product can be used to deliver agents. |
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| DC65438 |
SM-102 Analog 2(Compound 8-8)
Featured
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SM-102 Analog 2(Compound 8-8) is a lipid compound. SM-102 Analog 2(Compound 8-8) is involved in the synthesis of lipid nanoparticles compositions. SM-102 Analog 2(Compound 8-8) has potential applications in the transportation of biologically active substances. |
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| DC65439 |
LNP Lipid-6
Featured
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LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP). |
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| DC88888 |
Lipidoid XMaN6 |
Lipidoid XMaN6 is an ionizable lipid with universality was screened
out from the adamantyl-based ionizable lipid series, which could
functionally deliver highly diverse types of nucleic acids. Among
them, the XMaN6 iLNPs were the best-delivering vectors.
XMaN6 was used to deliver mRNA, siRNA, pDNA, and cyclic
dinucleotide into different cells, including human primary
hepatocytes, HEK293T, Huh7, HepG2, and U2OS cell, with nontoxicity
after a single dose.The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect, 2) mRNA into mouse liver, 3) plasmid DNA, 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic. |
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| DC85655 |
ssPalmE-P4C2 |
ssPalmE-P4C2 contained vitamin E (α-tocopherol) as a hydrophobic scaffold instead of oleic acid. ssPalmE-P4C2 was reported to have the ability to deliver siRNA to the liver. LNPssPalmE-P4C2 and LNPssPalmO-P4C2 showed a comparable knockdown efficiency (15.4 ± 8.7% and 19.2 ± 4.4%, respectively). |
|
| DC60471 |
Lipid 16 |
Lipid 16 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads. Lipid 16 as a potent cell type-specific ionizable lipid for the CD11bhi macrophage population without an additional targeting moiety. |
|
| DC86805 |
Lipid 23
Featured
|
Lipid 23 is an ionizable cationic amino lipid (pKa = 5.7) that has been used with other lipids in the formulation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing lipid 23 and encapsulating an mRNA reporter accumulate specifically in the mouse liver. |
|
| DC60475 |
CL4F8-6 |
CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 Intravenous administration of LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR. |
|
| DC60476 |
1O14 |
1O14 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 1O14-containing LNPs have been used for the delivery of IL-1β siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury induced by LPS and galactosamine (GalN). |
|
| DC60478 |
ALC-0366
Featured
|
ALC-0366 is an ionizable cationic lipid (pKa = 6.25).It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. |
|
| DC89030 |
SM-102 IMPURITY 1
Featured
|
|
|
| DC89031 |
SM-102 IMPURITY 2(SM-102 N-oxide) |
SM-102 N-oxide is potential impurity in commercial preparations of SM-102. |
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| DC60482 |
DIM7S |
DIM7S is a sugar-alcohol-derived ionizable lipid with mannitol as the precursor. DIM7S LNP is 10-fold, 30-fold, 20-fold, 4-fold and 3-fold superior in mRNA delivery than Lipo 3K, Electro, ALC-0315, MC3 and SM-102, respectively. DIM7S LNP enables effective CD40 mRNA delivery into human peripheral blood monocyte-derived DCs without obvious cytotoxicity. |
|
| DC60483 |
LIS10W |
LIS10W is a sugar-alcohol-derived ionizable lipid with L-sorbitol as the precursor. CD40L-LIS10W in the CATCH (CD40L-LIS10W+CD40-BDMCs) treatment simultaneously induces ICD and CD40L expressions in tumoural tissues, which enables to activate both endogenous DCs and adoptively transferred CD40-BMDCs. |
|
| DC89101 |
C12-4 (C12-494,Lipid A-4)
Featured
|
C12-4 (C12-494,Lipid A-4) is a branched-chain ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing lipid A4 and encapsulating an mRNA reporter accumulate in the uterus, placenta, and ovaries, as well as to the spleen and liver, in pregnant mouse dams unlike LNPs containing the branched-chain ionizable cationic lipidoid C12-200, which primarily accumulate in the liver. Intravenous administration of LNPs containing lipid A4 and encapsulating mRNA encoding VEGF increase placental VEGFR1 levels and mean fetal blood vessel area without inducing liver damage in pregnant mouse dams. |
|
| DC60485 |
IAJD93 |
IAJD93(IAJD-93) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery. |
|
| DC60486 |
IAJD 288 |
IAJD 288(IAJD-288) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery. |
|
| DC60487 |
IAJD249 |
IAJD249(IAJD-249) is a pentaerythritol-based one-component ionizable amphiphilic Janus Dendrimer (IAJD), delivery systems for mRNA delivery. |
|
| DC60488 |
CL1H6
Featured
|
CL1H6 is an ionizable lipid and CL1H6-LNP is capable of efficiently introducing both siRNA and mRNA into NK-92 cells. |
|
| DC60489 |
LIPID 331 |
Lipid 331 is a biodegradable cyclic ionizable lipid. LNPs containing Lipid 331 result in robust transfection in the nasal and lung tissues of mice and efficient transfection of lung epithelial cells and lung-resident APCs. Lipid 331 is a promising candidate for mRNA vaccine delivery, offering the potential for further enhancing the potency of mRNA vaccines. |
|
| DC65560 |
GalNAc-L96 free base
Featured
|
GalNAc-L96 free base, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs. |
|
| DC65559 |
GalNAc-L96 Phosphoramidite
Featured
|
|
|
| DC65561 |
GalNac-L96 analog
Featured
|
GalNAc-L96 analog is an intermediate in the synthesis of the asialoglycoprotein receptor (ASGPR) ligand GalNAc-L96. |
|
| DC65562 |
GalNAc-NAG-25 Phosphoramidite
Featured
|
|
|
| DC65563 |
GalNAc-L96-CPG
Featured
|
|
|
| DC65564 |
GalNAc-L96-PS
Featured
|
|
|
| DC65565 |
GalNac-L96
Featured
|
GalNac-L96, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs[1]. |
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