Cat. No. | Product name | CAS No. |
DC46377 |
ML-SA1
Featured
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. |
332382-54-4 |
DC46465 |
Capsiate
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1. |
205687-01-0 |
DC46466 |
Dihydrocapsiate
Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease. |
205687-03-2 |
DC46699 |
9-Phenanthrol
9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, without effects on TRPM5. |
484-17-3 |
DC46871 |
Vocacapsaicin
Featured
Vocacapsaicin (CA-008), a prodrug of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief. |
1931116-86-7 |
DC46872 |
Evifacotrep
Featured
Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. |
2413739-88-3 |
DC47246 |
SB 452533
SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8. |
459429-39-1 |
DC47287 |
Tivanisiran
Featured
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1). |
1848224-71-4 |
DC47315 |
ML-SI3
Featured
ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively. |
891016-02-7 |
DC47322 |
4-(Phenyldiazenyl)benzoic acid
4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used as pharmacological tools for study of pain signaling. |
1562-93-2 |
DC47323 |
TRPA1 Antagonist 3
TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel. |
71291-80-0 |
DC47876 |
TRPM8 antagonist 3
TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM. |
2102179-29-1 |
DC48205 |
Oleoyl serotonin
Oleoyl Serotonin is a TRPV1 antagonist with IC50 value of 2.57 μM for human TRPV1. |
1002100-44-8 |
DC48206 |
TRPA1-IN-1
TRPA1-IN-1 is a potent, selective, and orally bioavailable TRPA1 small molecule antagonist. |
2376824-92-7 |
DC48207 |
TRPV4 antagonist 3
TRPV4 antagonist 3 is a TRPV4 antagonist (pIC50 = 8.4). |
2681273-35-6 |
DC48208 |
Motugivatrep
Motugivatrep is the potent antagonist of transient receptor potential type 1 (TRPV1). Motugivatrep has a wide range of usefulness in treating drugs, urine tabletops, and respiratory diseases (extracted from patent WO2007010383A1). |
920332-28-1 |
DC48736 |
TRPC6-IN-2
The compound inhibits TRPC proteins, and more specifically inhibits the TRPC6 protein. |
2308595-83-5 |
DC48776 |
TRPC5-IN-1
TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor with 50.5 % Inhibition for TRPC5 at 3 μM. TRPC5-IN-1 can be used for the research of chronic kidney disease (CKD). |
2265215-18-5 |
DC49713 |
N-Oleoyldopamine
N-Oleoyldopamine (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist. N-Oleoyldopamine (OLDA) can crosses the blood-brain barrier. N-oleoyl-dopamine protects the heart against ischemia-reperfusion injury via activation of TRPV1. |
105955-11-1 |
DC49714 |
TRPC5 modulator-1
TRPC5 modulator-1 (Compound 9) is a TRPC5 modulator with an IC50 of <1 nM for the research of neuropsychiatry disorders. |
1877343-90-2 |
DC49715 |
TRPC5-IN-2
TRPC5-IN-2 is a potent TRPC5 inhibitor (WO2019055966A2, Compound IO). |
2304552-99-4 |
DC49716 |
(1R,2R)-ML-SI3
(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3. |
2418594-00-8 |