Cat. No. | Product name | CAS No. |
DC9735 |
SB-366791
Featured
SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research. |
472981-92-3 |
DC9635 |
SB-705498
Featured
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
501951-42-4 |
DC9722 |
SKF96365
Featured
SKF96365 is blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. |
130495-35-1 |
DC9622 |
SN 2
SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM. |
823218-99-1 |
DC7755 |
TRCP6 inhibitor(SAR7334)
Featured
TRPC6 inhibitor is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor. |
1333207-63-8 |
DC11472 |
TRPM8 antagonist 14
Featured
TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. |
259674-19-6 |
DC28276 |
GSK1702934A
GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3. |
924377-85-5 |
DC28359 |
Hyperforin dicyclohexylammonium salt
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect. |
238074-03-8 |
DC28427 |
Resolvin D2
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons. |
810668-37-2 |
DC28702 |
GFB-8438
Featured
GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model. |
2304549-73-1 |
DC28758 |
Umbellulone
Featured
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism. |
546-78-1 |
DC29157 |
Methyl syringate
Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a TRPA1 agonist.. |
884-35-5 |
DC41624 |
L-R4W2
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 may act as a potent analgesic. |
206350-79-0 |
DC41625 |
L-R4W2 TFA
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 TFA may act as a potent analgesic. |
|
DC42162 |
AP-18
AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM. |
55224-94-7 |
DC45285 |
IA-Alkyne
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. |
930800-38-7 |
DC45286 |
CIM0216
CIM0216, a potent and selective agonist of TRPM3, has the ability to open two distinct cation-permeable pores in TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts as a powerful tool for use in investigating the physiological roles of TRPM3, and can be used for neurogenic inflammation research. |
1031496-06-6 |
DC45287 |
TRPC6-PAM-C20
Featured
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 selectively activates TRPC6 over other TRP channels and also activates TRPA1. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50=2.37 μM). |
667427-75-0 |
DC45288 |
AMG2850
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. |
1470018-52-0 |
DC45289 |
OptoBI-1
OptoBI-1 is a photochromic TRPC3 agonist, which asts as a photopharmacological tool to control of neuronal firing. |
2415272-11-4 |
DC45849 |
GSK2332255B
GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels. |
1366233-41-1 |
DC45871 |
Methyl kakuol
Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM. |
70342-29-9 |