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Home > PROTACs > E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

  Cat. No.:  DC39625   Featured
Chemical Structure
2064292-52-8
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More than 5000 active chemicals with high quality for research!
Field of application
VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2064292-52-8
Chemical Name: (2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride
Synonyms: VH-03 linker; VH 03 linker; VH03 linker; VH03-linker
SMILES: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Formula: C32H50ClN5O8S
M.Wt: 700.29
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication: [1]. Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20170008904A1.
Description: E3 ligase Ligand-Linker Conjugates 7 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Target: E3 Ligase Ligand-Linker Conjugate[1]
In Vitro: E3 ligase Ligand-Linker Conjugates 7 is from patent US20170008904, example 3, 0376. E3 ligase Ligand-Linker Conjugates 7 is part of compound A1895[1].
References: [1]. US20170008904
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
DC39625 (S,R,S)-AHPC-PEG4-NH2 hydrochloride VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
DC50079 Thalidomide-O-amido-C5-NH2 Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
DC50078 (S,R,S)-AHPC-Me-C8-NH2 (S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
DC50077 (S,R,S)-AHPC-Me-C4-NH2 (S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
DC50076 (S,R,S)-AHPC-Me-C3-NH2 (S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
DC50075 (S,R,S)-AHPC-Me-C2-NH2 (S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
DC50074 (S,R,S)-AHPC-Me-C1-NH2 (S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
DC50070 (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50068 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
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