Acid-degradable DSEP-PEG2000|DC Chemicals

Cas No.:

Description:

Acid-degradable DSPE-PEG2000 composed of DSPE-PEG2000 is synthesized with the azido-acetal linker azido-acetal linker, which is stable at physiological pH (7.4) but rapidly hydrolyzes in the acidic environment of endosomes. This two-step mechanism (reduction followed by acid hydrolysis) ensures that ADP-LNPs remain stable during circulation but quickly release their payload upon entering target cells.It is designed by DC Chemicals

MSDS

Cat. No.	Product name	Field of application
DC40169	DMG-PEG2000	DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modific
DC58047	DSPE-PEG 2000	PEG2000-DSPE is used for creating micelles that are able to carry drugs with low solubility.
DC52020	ALC-0159	ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid). Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.
DC13590	Acid-degradable DSEP-PEG2000	Acid-degradable DSPE-PEG2000 composed of DSPE-PEG2000 is synthesized with the azido-acetal linker azido-acetal linker, which is stable at physiological pH (7.4) but rapidly hydrolyzes in the acidic environment of endosomes. This two-step mechanism (reduction followed by acid hydrolysis) ensures that ADP-LNPs remain stable during circulation but quickly release their payload upon entering target cells.It is designed by DC Chemicals
DC67161	MPEG-2000-DPPE Na	DPPE-MPEG(2000) is a PEGylated form of 1,2-dipalmitoyl-rac-glycero-3-PE (DPPE). It has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention.
DC67112	DPPE-PEG2000	DPPE-PEG2000 (16:0 PEG2000 PE) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo.
DC67111	18:1 PEG2000 PE	18:1 PEG2000 PE (18:1 PEG-PE) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE can be used for drug delivery.
DC60638	Acid-degradable PEG Lipid (ADP-2k)	Acid-degradable PEG Lipid (ADP) composed of polyethylene glycol lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo.
DC65786	mPEG2000-DSPE	mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.
DC65770	DMPE-mPEG2000(Na salt)