AEBSF-hydrochloride

Cas No.:	30827-99-7
Chemical Name:	AEBSF hydrochloride
Synonyms:	4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride;4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride;AEBSF hydrochloride;4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research];4-(2-AMINOETHYL)BENZENE- SULFONYL FLUORIDE;4-(2-AMINOETHYL)-BENZENESULFONYL FLUORIDE;4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl;AEBSF;AEBSF (hydrochloride);Pefabloc® SC;4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride,AEBSF;Pefabloc SC;4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride;Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride;4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride;s7378;NSC-727364;EU-0100132;Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1);DTXSID60184830;M01245;P-1195;Pefabloc;Benzenesulfonyl fluoride, p-(2-aminoethyl)-, hydrochloride;30827-99-7;4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HCL [FOR BIOCHEMICAL RESEARCH];MFCD00132962;AC-36097;(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride;AEBSF HCl;SR-01000075690;AKOS015847774;A 8456;NSC 727364;Tox21_500132;Z1741982548;LP00132;A-5440;4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, >=97%;Pefabloc(R) SC, certified reference material, TraceCERT(R);4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride;NCGC00260817-01;EX-A2487;SMR001230821;BCP32155;Pefabloc, Antibiotic for Culture Media Use Only;DHA6VL95HL;SR-01000075690-1;4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochloride;Pefabloc(R) SC, analytical standard;30827-99-7 (HCl);SY007034;4-(2-Aminoethyl)Benzenesulfonyl Fluoride HCl;A820639;EN300-6762645;NCGC00093623-01;FT-0616512;UNII-DHA6VL95HL;2-AMINOETHYLPHENYLSULFONEHYDROCHLORIDE;T70748;AEBSF, Hydrochloride;FS-5456;SCHEMBL25973;NSC727364;CHEMBL1256178;CCG-207883;SW219355-1;4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride [for biochemical research];AEBSF-hydrochloride;HY-12821;MLS002153464;4-(2-aminoethyl)-benzenesulfonylfluoride hydrochloride;AEBSF HCl Biochemistry grade;4-(2-Aminoethyl)benzenesulfonylfluoridehydrochloride
SMILES:	O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl
Formula:	C8H10NO2FS.HCl
M.Wt:	239.69484
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	AEBSF is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
In Vivo:	AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection[3]. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model[4].
In Vitro:	AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural[1]. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β[2]. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern[4].