AG-120 (Ivosidenib)
Cat. No.: DC8051
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Chemical Structure
1448347-49-6
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Field of application
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.
| Cas No.: |
1448347-49-6 |
| Chemical Name: |
Ivosidenib |
| Synonyms: |
Ivosidenib;AG120;Tibsovo;Q2PCN8MAM6;(2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;(S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;RG120;ivosidenibum;(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-o |
| SMILES: |
ClC1=C([H])C([H])=C([H])C([H])=C1[C@@]([H])(C(N([H])C1([H])C([H])([H])C(C1([H])[H])(F)F)=O)N(C1C([H])=NC([H])=C(C=1[H])F)C([C@]1([H])C([H])([H])C([H])([H])C(N1C1C([H])=C(C#N)C([H])=C([H])N=1)=O)=O |
| Formula: |
C28H22ClF3N6O3 |
| M.Wt: |
582.9609 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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