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ALLO-1

  Cat. No.:  DC8570   Featured
Chemical Structure
37468-32-9
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More than 5000 active chemicals with high quality for research!
Field of application
ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 37468-32-9
Chemical Name: ALLO-1
Synonyms: ALLO-1;1-Benzyl-3-(4-chlorophenyl)-5-methyl-2,4-imidazolidinedione;1-Benzyl-3-(4-carbamoylphenoxy)-pyrrolidin;1-benzyl-3-(4-chloro-phenyl)-5-methyl-imidazolidine-2,4-dione;4-(1-BENZYLPYRROLIDIN-3-YLOXY)BENZAMIDE;AG-E-91623;Benzamide,4-[[1-(phenylmethyl)-3-pyrrolidinyl]oxy]-;Benzamide,p-[(1-benzyl-3-pyrrolidinyl)oxy]- (8CI);CTK4G1613;KB-185568;3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione
SMILES: CC1N(CC2=CC=CC=C2)C(=O)N(C2=CC=C(Cl)C=C2)C1=O
Formula: C17H15ClN2O2
M.Wt: 314.766203165054
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif[1].
Target: Autophagy[1]
References: [1]. Sato M, et al. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Nat Cell Biol. 2018 Jan;20(1):81-91.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC8570 ALLO-1 ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).
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