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ARP-100

  Cat. No.:  DC28161   Featured
Chemical Structure
704888-90-4
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Field of application
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 704888-90-4
Chemical Name: ARP 100
Synonyms: N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide;Acetamide,2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-;ARP 100;N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide;N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide;2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-Methylethoxy)aMino]-N-hydroxyacetaMide;MMP-2 Inhibitor III;ARP-100
SMILES: O=C(NO)CN(OC(C)C)S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O
Formula: C17H20N2O5S
M.Wt: 364.4161
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2].
Target: MMP-2:12 nM (IC50) MMP-9:0.2 μM (IC50) MMP-3:4.5 μM (IC50) MMP-1:>50 μM (IC50) MMP-7:>50 μM (IC50)
In Vitro: ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations[1].
References: [1]. Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50. [2]. Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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