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| Cas No.: | 796-42-9 |
| Chemical Name: | N'-[(Z)-(2-Oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide |
| Synonyms: | 2-hydroxy-1-naphthylaldehyde Isonicotinoyl Hydrazone;(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;NSC525357;1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine;isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide];1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid;2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone;AC1MPQ3B;2-hydroxy-1-napthaldehyde isonicotinoylhydrazone;Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid];(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide; NSC525357; 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine; isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide]; 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid; 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone; AC1MPQ3B; 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone; Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid]; 1-Isonicotinoyl-5;2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone;311 Iron Chelator;AS-8351;NSC-51355;AS8351;N'-[(2-hydroxy-1-naphthyl)methylene]isonicotinohydrazide;N'-[(1E)-(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide;NSC51355;N'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide;2- HYDROXY-1-NAPHTHALDEHYDE-ISONICOTINOYLHYDRAZONE;N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide;STK037070;NE57591;AS 8351 |
| SMILES: | O([H])C1C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C2C=1/C(/[H])=N/N([H])C(C1C([H])=C([H])N=C([H])C=1[H])=O |
| Formula: | C17H13N3O2 |
| M.Wt: | 291.3040 |
| Purity: | >98% |
| Sotrage: | 4°C for 1 year, -20°C for more than 2 years |
| Description: | AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells. |
| In Vitro: | AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2]. |
| References: | [1]. Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916. [2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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