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AS-8351

  Cat. No.:  DC9840   Featured
Chemical Structure
796-42-9
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More than 5000 active chemicals with high quality for research!
Field of application
AS 8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 796-42-9
Chemical Name: N'-[(Z)-(2-Oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
Synonyms: 2-hydroxy-1-naphthylaldehyde Isonicotinoyl Hydrazone;(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;NSC525357;1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine;isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide];1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid;2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone;AC1MPQ3B;2-hydroxy-1-napthaldehyde isonicotinoylhydrazone;Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid];(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide; NSC525357; 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine; isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide]; 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid; 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone; AC1MPQ3B; 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone; Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid]; 1-Isonicotinoyl-5;2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone;311 Iron Chelator;AS-8351;NSC-51355;AS8351;N'-[(2-hydroxy-1-naphthyl)methylene]isonicotinohydrazide;N'-[(1E)-(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide;NSC51355;N'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide;2- HYDROXY-1-NAPHTHALDEHYDE-ISONICOTINOYLHYDRAZONE;N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide;STK037070;NE57591;AS 8351
SMILES: O([H])C1C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C2C=1/C(/[H])=N/N([H])C(C1C([H])=C([H])N=C([H])C=1[H])=O
Formula: C17H13N3O2
M.Wt: 291.3040
Purity: >98%
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.
In Vitro: AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2].
References: [1]. Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916. [2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC7740 ML-324 ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC50 = 920 nM)
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DC10586 KDM4D-IN-1 KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
DC7614 IOX1 IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
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