IOX1|cas 5852-78-8|supplier DC Chemicals

Cas No.:	5852-78-8
Chemical Name:	8-Hydroxy-5-quinolinecarboxylic acid
Synonyms:	8-Hydroxyquinoline-5-carboxylic Acid;5-Carboxy-8-hydroxyquinoline;IOX 1;8-Hydroxy-5-quinolinecarboxylic acid;8-Hydroxy-chinolin-5-carbonsaeure;8-Hydroxy-chinolin-carbonsaeure-(5);8-hydroxy-quinoline-5-carboxylic acid;8XQ;AC1LA0UV;CHEMBL1230640;IOX-1;SureCN6068195;UNII-JM015YQC1C;IOX1;5-carboxy-8HQ;5-Quinolinecarboxylic acid, 8-hydroxy-;JM015YQC1C;4jht;4ie4;MLS002729056;GTPL8230;AOB6499;JGRPKOGHYBAVMW-UHFFFAOYSA-N;HMS3653E21;BCP16996;s7234;BDBM50396018;2184AH;IOX1, >=97% (HPLC);8-hydroxy-quinoline-5-c
SMILES:	O([H])C1C([H])=C([H])C(C(=O)O[H])=C2C([H])=C([H])C([H])=NC2=1
Formula:	C₁₀H₇NO₃
M.Wt:	189.1675
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC7636	RN-1 Hydrochloride	RN-1 is an inhibitor of lysine specific demethylase 1 (LSD1); exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively.
DC5204	OG-L002	OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
DC7740	ML-324	ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC50 = 920 nM)
DC11106	Vafidemstat (ORY-2001)	Vafidemstat (ORY-2001) is an oral, brain penetrant drug that inhibits LSD1 and MAOB by reducing cognitive impairment, including memory loss and neuroinflammation. It also has neuroprotective effects.
DC10586	KDM4D-IN-1	KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
DC7614	IOX1	IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
DC8491	GSK2879552	GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
DC8385	Disodium (R)-2-Hydroxyglutarate	Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.