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| Cas No.: | 2098902-68-0 |
| Chemical Name: | Kdm4D-IN-1 |
| Synonyms: | KDM4D-IN-1;BCP32624;BDBM50242878;s1059 |
| SMILES: | O=C1C2C([H])=C([H])C([H])=NC=2N2C(=C(C#N)C(C([H])([H])[H])=N2)N1[H] |
| Formula: | C11H7N5O |
| M.Wt: | 225.2062 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. |
| In Vitro: | KDM4D-IN-1 (Compound 10r) is the most potent one with an IC50 value of 0.41±0.03 μM against KDM4D. KDM4D-IN-1 displays almost no activity against KDM2B, KDM3B, and KDM5A (IC50>10 μM), indicating that KDM4D-IN-1 has a good selectivity for KDM4D against other selected KDMs[1]. |
| References: | [1]. Fang Z, et al. Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3201-3204. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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