AZD9362|AZD-9362|IGF-IR/InsR inhibitor

Cas No.:	1905412-80-7
Synonyms:	AZD 9362;AZD-9362
SMILES:	CC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C (C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
Formula:	C₂₄H₂₇ClN₈O₂
M.Wt:	494.98
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZD-9362 is dual IGF-IR/InsR inhibitor. AZD9362 inhibits autophosphorylation of IGF IR in fibroblasts from an IGF IR knockout mouse stably transfected with human IGF IR, as well as autophosphorylation of InsR in CHO cells transfected with human InsR.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC40124	NBI-31772 hydrate	NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects.
DC28921	I-OMe-Tyrphostin AG 538	I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.
DC2069	IGF-1R inhibitor GS1904529A	GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.
DC11760	BI 885578	BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
DC10112	AZD9362	AZD-9362 is dual IGF-IR/InsR inhibitor.