BI 885578|BI-885578;BI885578

Cas No.:
Chemical Name:	(S)-N-(1-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)-1H-pyrazol-3-yl)-2,5-dimethyl-1-phenyl-4,5-dihydro-2H-pyrazolo[4,3-f]quinazolin-7-amine
Synonyms:	BI-885578;BI885578
SMILES:	N1=C2C(C3=C(C4=CC=CC=C4)N(C)N=C3C[C@H]2C)=CN=C1NC1C=CN(CCN2CCN(CCOC)CC2)N=1
Formula:	C₂₉H₃₇N₉O
M.Wt:	527.677
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively; inhibits IGF1R/InsR cellular autophosphorylation with IC50 of 5 nM/5 nM respectively; significantly reduces the growth of xenografted human GEO and CL-14 colon carcinoma tumors, displays an acceptable tolerability profile in mice.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC40124	NBI-31772 hydrate	NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects.
DC28921	I-OMe-Tyrphostin AG 538	I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.
DC2069	IGF-1R inhibitor GS1904529A	GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.
DC11760	BI 885578	BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
DC10112	AZD9362	AZD-9362 is dual IGF-IR/InsR inhibitor.