Andarine (GTX-007) |cas 401900-40-1|DC Chemicals

Cas No.:	401900-40-1
Chemical Name:	Andarine
Synonyms:	Ostarine;N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide;Andarine;Andarine(S-4);(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide;(S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide;Andarine (GTX-007);MK-2866;Propanamide, 3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-, (2S)-;S4 (Andarine);S-4, andarine;GTx-007;GTX007;MK2866;S-3-(4-Acetylamino-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide;S-4;UNII-7UT2HAH49H;Andarine, S-4;SARM S-4;7UT2HAH49H;S-4 cpd;ANDARINE;S4;Andarine met;Andarine/;(S)-Andarine;ANDARINE (S4);M
SMILES:	FC(C1=C(C([H])=C([H])C(=C1[H])N([H])C([C@](C([H])([H])[H])(C([H])([H])OC1C([H])=C([H])C(=C([H])C=1[H])N([H])C(C([H])([H])[H])=O)O[H])=O)[N+](=O)[O-])(F)F
Formula:	C₁₉H₁₈F₃N₃O₆
M.Wt:	441.3579
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist.

References:

[1]. Thevis M, Geyer H, Kamber M, Sch?nzer W.Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product.Drug Test Anal. 2009 Aug;1(8):387-92. [2]. Thevis M, Thomas A, Fussh?ller G, Beuck S, Geyer H, Sch?nzer W.Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes.Rapid Commun Mass Spectrom. 2010 Aug [3]. Thomas A, Geyer H, Sch?nzer W, Crone C, Kellmann M, Moehring T, Thevis M.Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer.Anal Bioanal Chem. 2012 May;40 [4]. Guddat S, Solymos E, Orlovius A, Thomas A, Sigmund G, Geyer H, Thevis M, Sch?nzer W.High-throughput screening for various classes of doping agents using a new 'dilute-and-shoot' liquid chromatography-tandem mass spectrometry multi-target approach.Drug Tes [5]. Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005 Jun;5(3):173-88.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC10811	S23	S23 is a novel Selective Androgen Receptor Modulator(SARM)
DC4163	RU58841	RU58841 is a nonsteroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) comparable to hydroxyflutamide.
DC9657	RAD140	RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM).
DC8248	Ostarine(MK-2286)	Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism.
DC8700	ODM-201(Darolutamide)	ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.
DC5069	Enzalutamide (MDV3100)	MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
DC7633	Ligandrol (VK5211, LGD-4033)	Ligandrol (LGD-4033) is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.
DC9738	GSK2881078	GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness.
DC8856	EPI-001	EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator
DC4160	CB-03-01	CB-03-01 is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use.

Andarine (GTX-007,S-4)