(S)-B-973B
Cat. No.: DC12033
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Chemical Structure
2244989-34-0
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Field of application
B-973 (B973) is a potent, selective α7 nAChR ago-PAM, denonstrates analgesic effect with attenuating pain behavior and decreasing paw edema in vivo.
| Cas No.: |
2244989-34-0 |
| Chemical Name: |
3-(3,4-Difluorophenyl)-N-[(1S)-1-[6-(4-pyridin-2-ylpiperazin-1-yl)pyrazin-2-yl]ethyl]propanamide |
| Synonyms: |
Benzenepropanamide, 3,4-difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]-;3-(3,4-Difluorophenyl)-N-[(1S)-1-[6-(4-pyridin-2-ylpiperazin-1-yl)pyrazin-2-yl]ethyl]propanamide;(-)-(S)-B-973B |
| SMILES: |
FC1=C(C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C(N([H])[C@@]([H])(C([H])([H])[H])C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])=O)F |
| Formula: |
C24H26F2N6O |
| M.Wt: |
452.4997 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
(-)-(S)-B-973B is a potent allosteric agonism and positive allosteric modulation (ago-PAM) for α7 nAChR, with antinociceptive activity[1]. |
| References: |
[1]. Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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