| Cas No.: | 648903-57-5 |
| Chemical Name: | 3-Pyridinecarboxamide,2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-,dihydrochloride |
| Synonyms: | 3-Pyridinecarboxamide,2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-,dihydrochloride;2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide,dihydrochloride;BAY 61-3606;BAY 61-3606 (dihydrochloride);BAY61-3606 dihydrochloride;BAY-61-3606;96PPV9GQ7A;2-((7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide dihydrochloride;C20H18N6O3.2ClH;HMS3746I13;BCP24726;3472AH;s7006;2-(7-(3,4-Dimethoxyphe;BAY 61-3606 dihydrochloride;2-(2-furanyl)benzonitrile;2-(2-Furyl)benzonitrile;648903-57-5 (HCl);BAY 61-3606 2HCl;BAY 61-3606 (dihydrochloride);BAY61-3606 dihydrochloride;BAY 61-3606;BAY 61-3606 hydrochloride;BAY 61-3606(dihydrochloride);bay 61-3606(hcl);BAY-613606;bay-61-3606 2hcl;BAY61-3606 dihydrochloride;BAY 61-3606;http:////www.amadischem.com/proen/548662/;http:////www.amadischem.com/proen/571789/ |
| SMILES: | O=C(N)C1C(NC2N3C=CN=C3C=C(C3C=C(OC)C(OC)=CC=3)N=2)=NC=CC=1.[H]Cl.[H]Cl |
| Formula: | C20H20Cl2N6O3 |
| M.Wt: | 463.31720161438 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | BAY 61-3606 (dihydrochloride) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase (IC50=10 nM) with no inhibitory effect on Btk, Fyn, Itk, Lyn, and Src. |
| In Vivo: | BAY 61-3606 (3, 10, 30, 100 mg/kg, p.o.) dose dependently inhibits the PCA reaction with an ED50 value of 8 mg/kg. In a bronchoconstriction model, BAY 61-3606 dose dependently inhibits the DNP-BSA-induced increase in pulmonary pressure, and the dose of 3 mg/kg shows statistically significant suppression[1]. |
| In Vitro: | BAY 61-3606 inhibits the release of various inflammatory mediators in a concentration-dependent manner. The IC50 values for the FcϵRI-mediated hexosaminidase release from a rat basophilic leukemia cell line, RBL-2H3, and serotonin release from rat peritoneal mast cells are found to be 46 and 17 nM, respectively. BAY 61-3606 inhibits FcϵRI-mediated histamine and tryptase release from HCMCs with IC50 values of 5.1 and 5.5 nM, respectively, in a manner similar to its effect on the degranulation of RBL-2H3 cells and rat peritoneal mast cells. BAY 61-3606 inhibits histamine release from leukocytes in high and low IgE groups equipotently, giving IC50 values of 8.1 and 10 nM, respectively[1]. BAY 61-3606 affects viability in cells expressing mutant K-RAS or B-RAF through a MAPK-independent pathway. Inhibition of SYK is not responsible for the BAY 61-3606 effect on cell viability in colorectal cancer cells. MAP4K2 is a target for BAY 61-3606 that modulates the response of wild-type cells to AZ-628[2]. BAY61-3606 has a 50% Cytotoxicity Concentration (CC50) value of greater than 100 μM, and it inhibits AD169 replication[3]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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