BLU554(Fisogatinib)

Cas No.:	1707289-21-1
Chemical Name:	Fisogatinib
Synonyms:	BLU-554;BLU 554;Fisogatinib;BLU554;N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide;Fisogatinib [INN];fisogatinib (proposed INN);5Q7R99CKV2;BLU 554 [WHO-DD];GTPL10220;MGZKYOAQVGSSGC-DLBZAZTESA-N;N-((3S,4S)-3-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)oxan-4-yl)prop-2-enamide;CS3008;s8503;N-[(3S,
SMILES:	ClC1C(=C([H])C(=C(C=1C1C([H])=C([H])C2C(C=1[H])=C([H])N=C(N=2)N([H])[C@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@]1([H])N([H])C(C([H])=C([H])[H])=O)Cl)OC([H])([H])[H])OC([H])([H])[H]
Formula:	C24H24Cl2N4O4
M.Wt:	503.3778
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.

In Vitro:

Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3[1].