H3B-6527

  Cat. No.:  DC10033   Featured
Chemical Structure
1702259-66-2
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More than 5000 active chemicals with high quality for research!
Field of application
H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.
Cas No.: 1702259-66-2
Chemical Name: N-[2-[[6-[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide
Synonyms: H3B-6527;N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide;4HTE364XIK;N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide;MBWRLLRCTIYXDW-UHFFFAOYSA-N;BDBM249396;BCP17555;AK684091;US9434697, 108;N-(2-((6-(((
SMILES: ClC1C(=C([H])C(=C(C=1N([H])C(N(C([H])([H])[H])C1C([H])=C(N=C([H])N=1)N([H])C1C([H])=C([H])C(=C([H])C=1N([H])C(C([H])=C([H])[H])=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])=O)Cl)OC([H])([H])[H])OC([H])([H])[H]
Formula: C29H34Cl2N8O4
M.Wt: 629.5375
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC10033 H3B-6527 H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.
DC10092 BLU554(Fisogatinib) BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.
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