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Amoscanate

  Cat. No.:  DC10698   Featured
Chemical Structure
100990-46-3
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Field of application
Amoscanate(nithiocyamine) is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,and is also highly active against hookworm
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 100990-46-3
Chemical Name: Amoscanate
Synonyms: CGP4540 (Amoscanate);(4-Isothiocyanato-phenyl)-(4-nitro-phenyl)-amine;Amoscanate;Nithiocyamine;Amoscanatum;Amoscanato;Ciba 9333 GO;4-(4-Nitroanilino)phenylisothiocyanat;4-Isothiocyanato-4'-nitrodiphenylamine;p-(p-Nitroanilino)phenyl isothiocyanate;4-isothiocyanato-N-(4-nitrophenyl)aniline;CGP 4540;4-Isothiocyanato-N-(4-nitrophenyl)benzenamine;C 9333 GO;GO 9333;CGP4540;X0MK46CVRB;ISOTHIOCYANIC ACID, p-(p-NITROANILINO)PHENYL ESTER;Benzenamine, 4-isothiocyanato-N-(4-nitrophenyl)- (9CI);(4-Isothiocyanato-ph
SMILES: S=C=NC1C=CC(=CC=1)NC1C=CC(=CC=1)[N+](=O)[O-]
Formula: C13H9N3O2S
M.Wt: 271.294461011887
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
In Vivo: Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1]. Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1]. Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1]. Amoscanate elicits massive ultrastructural damage in ependymal cells[1]. Animal Model: Sprague-Dawley rats[1] Dosage: 500 mg/kg Administration: P.o.; 10 days Result: Destructed ependyma and periventricular brain. Animal Model: Sprague-Dawley rats[1] Dosage: 250 and 500 mg/kg Administration: P.o.; 28 days Result: Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum. Animal Model: Sprague-Dawley rats[1] Dosage: 25~500 mg/kg Administration: P.o.; 20 days Result: Elicited progressive necrosis of ependymal.
References: [1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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