CK-636|cas 442632-72-6|DC Chemicals

Cas No.:	442632-72-6
Chemical Name:	N-[2-(2-Methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
Synonyms:	CK-636;CK 636;N-[2-[(9aS)-1,3,4,9a-tetrahydropyrido[3,4-b]indol-2-yl]ethyl]thiophene-2-carboxamide;CK0944636;CK-0944636;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide;N-[2-(2-methylindol-3-yl)ethyl]-2-thienylcarboxamide;N-(2-(2-methyl-1H-indol-3-yl)ethyl)thiophene-2-carboxamide;3dxk;ZERO/003249;Oprea1_603109;AOB6801;CK636;HMS3653J09;BCP09080;2325AH;SB19452;DB08235;ST038703;AK174334;BC600642
SMILES:	S1C([H])=C([H])C([H])=C1C(N([H])C([H])([H])C([H])([H])C1=C(C([H])([H])[H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)=O
Formula:	C₁₆H₁₆N₂Os
M.Wt:	284.376
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively.

In Vitro:

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. CK-636 prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50=22 µM)[1]. Additionally, CK-636-treated T cells exhibits elongated morphology with sharp pseudopodia at the leading edges, while the breadth of the CK-636-treated T cells is about 30% less than that of DMSO-treated T cells[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC72598	EG-011	EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas.
DC11475	CK-869	CK-869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex.
DC7386	CK-636	CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3.