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| Cas No.: | 442632-72-6 |
| Chemical Name: | N-[2-(2-Methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide |
| Synonyms: | CK-636;CK 636;N-[2-[(9aS)-1,3,4,9a-tetrahydropyrido[3,4-b]indol-2-yl]ethyl]thiophene-2-carboxamide;CK0944636;CK-0944636;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide;N-[2-(2-methylindol-3-yl)ethyl]-2-thienylcarboxamide;N-(2-(2-methyl-1H-indol-3-yl)ethyl)thiophene-2-carboxamide;3dxk;ZERO/003249;Oprea1_603109;AOB6801;CK636;HMS3653J09;BCP09080;2325AH;SB19452;DB08235;ST038703;AK174334;BC600642 |
| SMILES: | S1C([H])=C([H])C([H])=C1C(N([H])C([H])([H])C([H])([H])C1=C(C([H])([H])[H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)=O |
| Formula: | C16H16N2Os |
| M.Wt: | 284.376 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. |
| In Vitro: | CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. CK-636 prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50=22 µM)[1]. Additionally, CK-636-treated T cells exhibits elongated morphology with sharp pseudopodia at the leading edges, while the breadth of the CK-636-treated T cells is about 30% less than that of DMSO-treated T cells[2]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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