Capromorelin

Cas No.:	193273-69-7
Chemical Name:	Capromorelin tartrate
Synonyms:	N-{2-[(3aS)-3a-benzyl-2-methyl-3-methylidene-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-1-(benzyloxy)-2-oxoethyl}-2-methylalaninamide 2,3-dihydroxybutanedioate (1:1);(2R,3R)-2,3-Dihydroxysuccinic acid - N-{2-[(3aS)-3a-benzyl-2-meth yl-3-methylene-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5 -yl]-1-(benzyloxy)-2-oxoethyl}-2-methylalaninamide (1:1);N-{2-[(3aS)-3a-benzyl-2-methyl-3-methylidene-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-1-(benzyloxy)-2-oxoethyl};2-Amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate;CP 424391-18;CP-424391 tartrate;CaproMorelin Tartrate;Capromorelin (Tartrate);Capromorelin tartrate [USAN];4150VMF5EP;Capromorelin tartrate (USAN);2-amino-N-((R)-1-((R)-3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R,3R)-2,3-dihydroxysuccinate;N-[(2R)-1-[(3aR)-3a-benzyl-2-methyl-3-oxo-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-1-oxo-3-phenylmethoxypropan-2-yl]
SMILES:	O=C1[C@@]2(C([H])([H])C3C([H])=C([H])C([H])=C([H])C=3[H])C(C([H])([H])C([H])([H])N(C([C@@]([H])(C([H])([H])OC([H])([H])C3C([H])=C([H])C([H])=C([H])C=3[H])N([H])C(C(C([H])([H])[H])(C([H])([H])[H])N([H])[H])=O)=O)C2([H])[H])=NN1C([H])([H])[H].O([H])[C@@]([H
Formula:	C32H41N5O10
M.Wt:	655.6954
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
In Vivo:	Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv[2].
In Vitro:	Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM[2].