cis-Diaminedichloroplatinum

Cas No.:	15663-27-1
Chemical Name:	cis-Diaminedichloroplatinum
Synonyms:	cis-Dichlorodiamineplatinum(II);cis-DDP;cis-Diammineplatinum(II) dichloride;cis-Diamminedichloroplatinum(II);cis-platinum(ii)diammine dichloride;Cisplatin;cis-Dichlorodiammineplatinum(II);cis-Platinum(II) diammine chloride;Platinumdiamminechloride;DichlorodiammineplatinumIIyelloworangextl;Cis-Diammineplatinum dichloride;(cis)-Diammineplatinum dichloride;cis-Dichlorodiammineplatinum (II), CISPLATIN (USP);Cisplatin (cis-DDP, CDDP, CACP, cis-Diammineplatinum(II) dichloride, cis-Diaminodichloroplatinum);cis-Platinous diamine dichloroplatin;CDDP;cis-Diamineplatinum(II) dichloride;cis-Diaminodichloroplatinum;cis-Diammineplatinum(II) dichloride (cis-Dichlorodiammine platinum(II);cis-Diaminedichloroplatinum(II);cis-Platinum(II) Diammine Dichloride;cis-Diaminedichloroplatinum;CPDC;cis-Diamminedichlorplatine;cis-Dichlorodiamine platinum;Diamminedichloroplatinum;Platinum diamine dichloride;Platinum, diamminedichloro-;trans-Diaminedichloroplatinum;DSSTox_CID_4983;DSSTox_RID_77611;DSSTox_GSID_24983;Platinoxan;Biocisplatinum;Platiblastin;Citoplationo;Cisplatyl;Abiplatin;Platidiam;Plastin;cisplatin complex;DDPt;cis-Platinum(II);Pt(II) Complex;cis Pt II;CPDD;dichloroplatinumdiamine;Platinum(IV) Complex;Platinum (II)
SMILES:	Cl[Pt-2]([NH3+])([NH3+])Cl
Formula:	Cl2H4N2Pt
M.Wt:	298.0292
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Cisplatin is a antineoplastic chemotherapy drug which works by cross-linking with DNA and causing DNA damage in cancer cells.
In Vivo:	In melanoma-bearing mice, Cisplatin (4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight[3]. Cisplatin administration results in significant increases in the kidney weight as a percentage of the total body weight, urine volume, serum creatinine, and blood urea nitrogenby about 132, 315, 797, and 556% in comparison with the control rats, respectively[4].
In Vitro:	Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK[1]. Cisplatin (50 μM) produces time-dependent apoptosis in renal proximal tubular cell (RPTCs), causing cell shrinkage, a 50-fold increase in caspase 3 activity, a 4-fold increase in phosphatidylserine externalization, and 5- and 15-fold increases in chromatin condensation and DNA hypoploidy, respectively[2].