Cas No.: | 52-24-4 |
SMILES: | S=P(N1CC1)(N2CC2)N3CC3 |
Formula: | C6H12N3PS |
M.Wt: | 189.21 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Thio-TEPA is a DNA alkylating agent, with antitumor activity. |
In Vivo: | Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice[2]. |
In Vitro: | Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM[1]. |