ATH686|ATH 686|CAS 853299-52-2|DC Chemicals

Cas No.:	853299-52-2
Chemical Name:	1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea
Synonyms:	ATH 686;ATH-686
SMILES:	N(C1=CC=C(OC2C=CN=C(N)N=2)C=C1)C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)=O
Formula:	C₂₅H₂₈F₃N₇O₂
M.Wt:	515.541
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase; selectively kills leukemic cells harboring mutant FLT3 with no apparent effect on cells harboring wild-type FLT3, via inhibition of FLT3 kinase activity; potently inhibits cell proliferation of FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells (IC50<1 nM), via induction of apoptosis.

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2018-0101

Cat. No.	Product name	Field of application
DC49069	MAX-40279 hemiadipate	MAX-40279 hemiadipate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemiadipate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032).
DC48999	MAX-40279 hemifumarate	MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032).
DC48860	MAX-40279	MAX-40279 is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032).
DC44219	FLT3-IN-3	FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.
DC28163	5'-Fluoroindirubinoxime	5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM.
DC10921	ATH686	ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.