CLK2 inhibitor Indazole1|Indazole1

Cas No.:
Chemical Name:	(S)-4-methyl-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine
Synonyms:	Indazole1
SMILES:	C(OC1=CC(C2C=CC3=C(C=2)C(C)=NN3)=CN=C1)[C@H](N)CC(C)C
Formula:	C₁₉H₂₄N₄O
M.Wt:	324.428
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases; rescues spine density in mouse brain slices at 300 nM; displays 96-fold more potent than TG003 in the CLK2 Caliper assay.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8594	ML167	ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
DC11004	CLK2 inhibitor Indazole1	CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.