ML167|cas 1285702-20-6|DC Chemicals

Cas No.:	1285702-20-6
Synonyms:	ML167; ML-167; ML 167; CID 44968231
SMILES:	CN(C1=CC=C(C)O1)C1C2C(=CC=C(C3OC(CO)=CC=3)C=2)N=CN=1
Formula:	C₁₉H₁₇N₃O₃
M.Wt:	335.35658
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrks) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas Dyrks interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM. It is more than 10-fold less active against the closely related kinases Clk1-3, Dyrk1A, and Dyrk1B (IC50s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8594	ML167	ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
DC11004	CLK2 inhibitor Indazole1	CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.