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| Cas No.: | 1285702-20-6 |
| Synonyms: | ML167; ML-167; ML 167; CID 44968231 |
| SMILES: | CN(C1=CC=C(C)O1)C1C2C(=CC=C(C3OC(CO)=CC=3)C=2)N=CN=1 |
| Formula: | C19H17N3O3 |
| M.Wt: | 335.35658 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrks) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas Dyrks interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM. It is more than 10-fold less active against the closely related kinases Clk1-3, Dyrk1A, and Dyrk1B (IC50s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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