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Home > Inhibitors & Agonists > GPCR > Prostaglandin Receptor

Omidenepag

  Cat. No.:  DC11043   Featured
Chemical Structure
1187451-41-7
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Field of application
Omidenepag is a potent, selective agonist human EP2 receptor with binding IC50/EC50 of 10/1.7 nM, >500-fold selectivity over EP1, EP3 and EP4 receptors; Omidenepag is the active form of Omidenepag Isopropyl (OMDI).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1187451-41-7
Chemical Name: (6-((4-(Pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid
SMILES: O=C(O)CNC1=NC(CN(CC2=CC=C(N3N=CC=C3)C=C2)S(=O)(C4=CC=CN=C4)=O)=CC=C1
Formula: C23H22N6O4S
M.Wt: 478.52
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Kirihara T, et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153. 2. Impagnatiello F, et al. Br J Pharmacol. 2018 Apr 18. doi: 10.1111/bph.14328. 3. Fuwa M, et al. J Ocul Pharmacol Ther. 2018 Jul 10. doi: 10.1089/jop.2017.0146. 4. Iwamura R, e
Description: Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC8348 TG6-10-1 TG6-10-1 is a cell-permeable,highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8 nM).
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DC8353 PF-04418948 PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).
DC11043 Omidenepag Omidenepag is a potent, selective agonist human EP2 receptor with binding IC50/EC50 of 10/1.7 nM, >500-fold selectivity over EP1, EP3 and EP4 receptors; Omidenepag is the active form of Omidenepag Isopropyl (OMDI).
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DC10785 MK-7246 MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
DC1009 Laropiprant MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively.
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