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Home > Inhibitors & Agonists > GPCR > Prostaglandin Receptor

Setipiprant(ACT129968)

  Cat. No.:  DC8624   Featured
Chemical Structure
866460-33-5
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More than 5000 active chemicals with high quality for research!
Field of application
Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 866460-33-5
Synonyms: ACT129968,ACT-129968,ACT 129968
SMILES: O=C(CN1C2C=CC(=CC=2C2CN(CCC1=2)C(=O)C1C=CC=C2C=1C=CC=C2)F)O
Formula: C24H19FN2O3
M.Wt: 402.42
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nM
Target: IC50 value: 6.0 nM Target: PGD2
In Vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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