ADX-102 (Reproxalap;NS-2)
Cat. No.: DC11097
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Chemical Structure
916056-79-6
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Field of application
ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease.
| Cas No.: |
916056-79-6 |
| Chemical Name: |
2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol |
| Synonyms: |
Reproxalap;NS-2;ADX102;ADX 102 |
| SMILES: |
CC(C1C(N)=CC2C(N=1)=CC=C(Cl)C=2)(O)C |
| Formula: |
C12H13ClN2O |
| M.Wt: |
236.699 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
1: Bansal N, Janveja C, Tewari R, Soni R, Soni SK. Highly thermostable and pH-stable cellulases from Aspergillus niger NS-2: properties and application for cellulose hydrolysis. Appl Biochem Biotechnol. 2014 Jan;172(1):141-56. doi: 10.1007/s12010-013-0511-9. Epub 2013 Sep 20. PubMed PMID: 24052336. |
| Description: |
Reproxalap (ADX-102) is a reactive aldehyde species (RASP) sequestering agent for the treatment of dry eye. Reproxalap (ADX-102) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal[1][2]. |
| References: |
[1]. Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.
[2]. Reproxalap Phase 2b Dry Eye Disease Results. |
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