| Cas No.: | 1416799-28-4 |
| Chemical Name: | 6-[[(3-Fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]pyridine-3-carboxylic acid |
| Synonyms: | AMG 333; AMG333;BCP30858;(S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid;6-[[(3-Fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]pyridine-3-carboxyl;AMG 333 |
| SMILES: | FC1=CC=CN=C1C(C1C=CC(=C(C=1)F)OC(F)(F)F)NC(C1C=CC(C(=O)O)=CN=1)=O |
| Formula: | C20H12F5N3O4 |
| M.Wt: | 453.319002151489 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
| Target: | IC50: 13 nM (TRPM8)[1] |
| References: | [1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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