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Razuprotafib

  Cat. No.:  DC11528   Featured
Chemical Structure
1008510-37-9
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More than 5000 active chemicals with high quality for research!
Field of application
Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1008510-37-9
Chemical Name: N-(4-{(2S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-phenylpropanamido}-2-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]ethyl}phenyl)sulfamic acid
SMILES: O=S(O)(NC1=CC=C(C[C@H](NC([C@@H](NC(OC)=O)CC2=CC=CC=C2)=O)C3=CSC(C4=CC=CS4)=N3)C=C1)=O
Formula: C26H26N4O6S3
M.Wt: 586.696
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor.
References: [1]. Kevin Peters, et al. METHODS OF TREATING DIABETIC NEPHROPATHY USING HPTPß INHIBITORS. WO2019165349A1
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC73789 K306 K306 is a small molecule agonist that specifically targets SH2-containing 5' inositol phosphatase 1 (SHIP1), an enzyme involved in regulating cellular signaling pathways. SHIP1 is a lipid phosphatase that hydrolyzes the 5' phosphate of phosphatidylinositol-3,4,5-trisphosphate (PIP3), converting it to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). This activity modulates the PI3K (phosphoinositide 3-kinase) signaling pathway, which is critical for cell survival, proliferation, and immune responses.
DC50265 GDC-1971 GDC-1971 showed outstanding potency in biochemical and cell models, and it had a predicted human PK profile that suggested it would achieve target engagement at reasonable doses. GDC-1971 showed an IC50 below the limit of detection of the assay (≪0.001 μM), while that IC50 shifted to 0.17 μM in the same biochemical assay with the constitutively active E76K SHP2 mutant.
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DC28481 (E/Z)-BCI(DUSP6 inhibitor) (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
DC11528 Razuprotafib Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor..
DC11638 BCI(NSC 150117) BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish.
DC12013 NSC45586 NSC45586 sodium is a selective inhibitor targeting the PP2C phosphatase domain within both PHLPP1 and PHLPP2 proteins. By blocking these phosphatases, it enhances AKT activation in neuronal cells.
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