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GDC-1971

  Cat. No.:  DC50265   Featured
Chemical Structure
2377352-49-1
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More than 5000 active chemicals with high quality for research!
Field of application
GDC-1971 showed outstanding potency in biochemical and cell models, and it had a predicted human PK profile that suggested it would achieve target engagement at reasonable doses. GDC-1971 showed an IC50 below the limit of detection of the assay (≪0.001 μM), while that IC50 shifted to 0.17 μM in the same biochemical assay with the constitutively active E76K SHP2 mutant.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2377352-49-1
Chemical Name: Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
Synonyms: Spiro[benzofuran-​2(3H)​,​4'-​piperidin]​-​3-​amine, 1'-​[3-​(3,​4-​dihydro-​1,​5-​naphthyridin-​1(2H)​-​yl)​-​1H-​pyrazolo[3,​4-​b]​pyrazin-​6-​yl]​-​, (3R)​-;Migoprotafib
SMILES: C1=CC2OC3(CCN(C4NC5C(C(N6CCCC7C6=CC=CN=7)=NN=5)=NC=4)CC3)[C@H](N)C=2C=C1
Formula: C25H26N8O
M.Wt: 454.53
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC50265 GDC-1971 GDC-1971 showed outstanding potency in biochemical and cell models, and it had a predicted human PK profile that suggested it would achieve target engagement at reasonable doses. GDC-1971 showed an IC50 below the limit of detection of the assay (≪0.001 μM), while that IC50 shifted to 0.17 μM in the same biochemical assay with the constitutively active E76K SHP2 mutant.
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