Imigliptin dihydrochloride|Imigliptin

Cas No.:	1314944-07-4
Chemical Name:	(R)-2-((7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)methyl)benzonitrile dihydrochloride
Synonyms:	Imigliptin
SMILES:	C(#N)C1=CC=CC=C1CN1C2=C(N3CCC[C@H](N)C3)C=C(C)N=C2N(C)C1=O.[H]Cl.[H]Cl
Formula:	C₂₁H₂₆Cl₂N₆O
M.Wt:	449.38
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM; displays no activity against DPP-8 and DPP-9 (IC50>100 uM); shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8108	DBPR108	DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 Nm.
DC11899	Gosogliptin dihydrochloride	A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
DC11898	Gosogliptin	A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
DC11536	Imigliptin dihydrochloride	A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.