Gosogliptin|PF-734200;PF 734200;PF734200;PF 00734200

Cas No.:	869490-23-3
Chemical Name:	(3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone
Synonyms:	PF-734200;PF 734200;PF734200;PF 00734200
SMILES:	C(N1CCC(F)(F)C1)([C@H]1C[C@@H](N2CCN(C3=NC=CC=N3)CC2)CN1)=O
Formula:	C₁₇H₂₄N₆OF₂
M.Wt:	366.40886
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM; demonstrates >200-fold selectivity over other members of the DPP family (DPP-2, DPP-3, DPP-8, and DPP-9) and the related serine proteases, FAP, aminopeptidase P, and propyl oligopeptidase; shows potential treatment for type 2 diabetes.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8108	DBPR108	DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 Nm.
DC11899	Gosogliptin dihydrochloride	A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
DC11898	Gosogliptin	A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
DC11536	Imigliptin dihydrochloride	A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.