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SPM-242

  Cat. No.:  DC11560  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective S1P3 antagonist with Ki of 0.25 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: (R)-2-amino-4-(2-chloro-4-((3-hydroxyphenyl)thio)phenyl)-2-(hydroxymethyl)butyl dihydrogen phosphate
Synonyms: SPM242
SMILES: P(OC[C@@](N)(CO)CCC1=CC=C(SC2=CC=CC(O)=C2)C=C1Cl)(O)(O)=O
Formula: C17H21ClNO6PS
M.Wt: 433.84
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective S1P3 antagonist with Ki of 0.25 nM; displays selectivity over other S1P receptors.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47220 Zectivimod Zectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases, chronic inflammatory diseases and immunoregulation disorders.
DC44942 H2L 5765834 H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.
DC42560 1-Oleoyl lysophosphatidic acid 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant LPA species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation. 1-Oleoyl lysophosphatidic acid increases SRE-drivenβ-galactosidase activity.
DC28324 LPA2 antagonist 2 LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM, which is ＞480-fold more selective than LPA3 (IC50 of 13.85 μM).
DC28232 CYM50260 CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
DC10392 S1p receptor agonist 1 S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2.
DC11561 SPM-242 racemate A potent, selective S1P3 antagonist with Ki of 0.25 nM.
DC11560 SPM-242 A potent, selective S1P3 antagonist with Ki of 0.25 nM.
DC11605 ONO-0300302 A novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM.
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