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BCI(NSC 150117)

  Cat. No.:  DC11638   Featured
Chemical Structure
1245792-51-1
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More than 5000 active chemicals with high quality for research!
Field of application
BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1245792-51-1
Chemical Name: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
Synonyms: NSC-150117;NSC150117
SMILES: C(=O)1C2=C(C=CC=C2)C(NC2CCCCC2)/C/1=C\C1=CC=CC=C1
Formula: C22H23NO
M.Wt: 317.43
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Shah SK, et al. ACS Med Chem Lett. 2015 Mar 18;6(5):513-7.
Description: BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5[1].
References: [1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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