G-9791|G 9791;G9791

Cas No.:	1926204-95-6
Chemical Name:	6-(2-Chloro-4-(3-methyl-2-oxopyridin-1(2H)-yl)phenyl)-8-(2-(3-fluoro-1-methylazetidin-3-yl)ethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Synonyms:	G 9791;G9791
SMILES:	C(NC)1=NC=C2C=C(C3=CC=C(N4C(=O)C(C)=CC=C4)C=C3Cl)C(=O)N(CCC(F)3CN(C)C3)C2=N1
Formula:	C₂₆H₂₆ClFN₆O₂
M.Wt:	508.98
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively; displays 57-fold selectivity over Lck kinase; inhibits the phosphorylation of residue S298 of MEK1 in EBC1 cells with IC50 of 33 nM.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46430	PF-3758309 dihydrochloride	PF-3758309 dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation.
DC11198	CZh226 hydrochloride	CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
DC11672	G-9791	A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively.