CZh226 hydrochloride|CZh-226;CZh 226

Cas No.:	2231440-94-9
Chemical Name:	(R)-(6-Chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)- quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride
Synonyms:	CZh-226;CZh 226
SMILES:	C(C1=NC(NC2C=C(C3CC3)NN=2)=C2C(=N1)C=CC(Cl)=C2)(N1CCN[C@@H](C)C1)=O.[H]Cl
Formula:	C₂₀H₂₃Cl₂N₇O
M.Wt:	448.352
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1; also exhibits excellent kinase spectrum selectivity against a panel of 54 kinases (<80% inhibition at 0.1 uM); potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro; CZh226 (CZh-226) is a valuable research probe for the further biological investigation of group II PAKs.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46430	PF-3758309 dihydrochloride	PF-3758309 dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation.
DC11198	CZh226 hydrochloride	CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
DC11672	G-9791	A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively.