GLPG-2222|ABBV-2222;ABBV2222;GLPG2222

Cas No.:	1918143-53-9
Chemical Name:	4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid
Synonyms:	ABBV-2222;ABBV2222;GLPG2222
SMILES:	C(O)(=O)C1=CC=C([C@H]2OC3=C(C=CC(OC(F)F)=C3)[C@@H](NC(C(C3=CC=C4OC(F)(F)OC4=C3)3CC3)=O)C2)C=C1
Formula:	C₂₈H₂₁F₄NO₇
M.Wt:	559.47
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM; is highly potent (5 nM) and efficacious in cells from multiple CF patient donors that have F508del homozygous mutation; shows potential in clinical trials in patients harboring the F508del CFTR mutation on at least one allele.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11096	Olacaftor	Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..
DC11678	GLPG-2222	GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.