sAJM-589|sAJM589

Cas No.:	2089-82-9
Chemical Name:	Benzo[a]phenazin-5-ol
Synonyms:	sAJM589
SMILES:	C12=CC=CC=C1C(O)=CC1C2=NC2C(=CC=CC=2)N=1
Formula:	C₁₆H₁₀N₂O
M.Wt:	246.269
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM; preferentially inhibits transcription of MYC target genes in P493-6 cell; suppresses cellular proliferation in diverse MYC-dependent cancer cell lines, including P493-6, Ramos, HL-60 and KG1a (IC50=0.8-2 uM); reduces Myc protein levels in these cells, possibly by promoting ubiquitination and degradation of Myc protein.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47701	c-Myc inhibitor 4	c-Myc inhibitor 4 is a potent, orally bioavailable c-MYC-reducing compound.
DC45837	MYC-IN-2	MYC-IN-2 is a MYC protein-protein inhibitor. MYC-IN-2 can be used for the research of cancer.
DC45348	NY2267	NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
DC40285	Lusianthridin	Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.
DC11684	sAJM-589	sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
DC11918	CMLD010509	A rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.